In the body, cells encounter a complex milieu of signals, including topographical cues, in
the form of the physical features of their surrounding environment. Imposed topography can …

… Bruder, JM, Monu, NC, Harrison, MW, and HoffmanKim, D. Fabrication of polymeric replicas
… Bruder, JM, Lee, AP, and Hoffman-Kim, D. Biomimetic materials replicating Schwann cell …

… Embryonic rat hippocampal neurites have been shown to grow both parallel to grooves with
d g of 1 μm and w g of 4 μm, and perpendicular to grooves with d g of 130 nm and w g of 1 …

This paper describes a method for preparing substrates with micropatterns of positive guidance
cues for the purpose of stimulating the growth of neurons. This method uses an oxidizing …

There is a high demand for in vitro models of the central nervous system (CNS) to study
neurological disorders, injuries, toxicity, and drug efficacy. Three-dimensional (3D) in vitro …

Traction Force Microscopy (TFM) is a powerful approach for quantifying cell-material
interactions that over the last two decades has contributed significantly to our understanding of …

Advances in neural tissue engineering require a comprehensive understanding of neuronal
growth in 3 dimensions. This study compared the gene expression of SH-SY5Y human …

Three-dimensional (3D) cell culture is an important tool that facilitates biological discoveries
by bridging the divide between standard two-dimensional cell culture and the complex, high-…

Background Successful nerve regeneration depends upon directed migration of morphologically
specialized repair state Schwann cells across a nerve defect. Although several groups …

… D. Cartoon shows method of categorizing the angle associated with each SC step into … D.
Bar graph of percentage of total trajectory spent with each type of contact between SC and the …