Rapid RNase L–driven arrest of protein synthesis in the dsRNA response without degradation of translation machinery
J Donovan, S Rath, D Kolet-Mandrikov, A Korennykh - Rna, 2017 - rnajournal.cshlp.org
Mammalian cells respond to double-stranded RNA (dsRNA) by activating a translation-inhibiting
endoribonuclease, RNase L. Consensus in the field indicates that RNase L arrests …
endoribonuclease, RNase L. Consensus in the field indicates that RNase L arrests …
Y-RNA and tRNA cleavage by RNase L mediates terminal dsRNA response
J Donovan, S Rath, D Kolet-Mandrikov, A Korennykh - bioRxiv, 2016 - biorxiv.org
Double-stranded RNA (dsRNA) is a danger signal that triggers endonucleolytic degradation
of RNA inside infected and stressed mammalian cells. This mechanism inhibits growth and …
of RNA inside infected and stressed mammalian cells. This mechanism inhibits growth and …
Regulation Mechanism of H. sapiens Tutase II
D Kolet-Mandrikov - 2017 - dataspace.princeton.edu
TUT2 is a human non-canonical poly(A) polymerase which polyadenylates, monoadenylates,
and monouridylates mRNA and miRNA in the cytoplasm (Chung et al., 2016). GLD2, the C…
and monouridylates mRNA and miRNA in the cytoplasm (Chung et al., 2016). GLD2, the C…
Spatial and temporal variation in plant hydraulic traits and their relevance for climate change impacts on vegetation
WRL Anderegg - New Phytologist, 2015 - Wiley Online Library
… Hirsch and D. Kolet-Mandrikov for assistance with data and study compilation. I thank L. …
Zeppel, D. Tissue, S. Pacala and three anonymous reviewers for insightful comments on the …
Zeppel, D. Tissue, S. Pacala and three anonymous reviewers for insightful comments on the …
Meta-analysis reveals that hydraulic traits explain cross-species patterns of drought-induced tree mortality across the globe
… We thank David Kolet-Mandrikov and Sophia Su for help in compilation of mortality and trait
data and Craig Allen of United States Geological Survey and Nate McDowell of Los Alamos …
data and Craig Allen of United States Geological Survey and Nate McDowell of Los Alamos …
Real-time 2-5A kinetics suggest that interferons β and λ evade global arrest of translation by RNase L
A Chitrakar, S Rath, J Donovan… - Proceedings of the …, 2019 - National Acad Sciences
Cells of all mammals recognize double-stranded RNA (dsRNA) as a foreign material. In
response, they release interferons (IFNs) and activate a ubiquitously expressed pseudokinase/…
response, they release interferons (IFNs) and activate a ubiquitously expressed pseudokinase/…
Enterovirus 2Apro Cleavage of the YTHDF m6A Readers Implicates YTHDF3 as a Mediator of Type I Interferon-Driven JAK/STAT Signaling
Enteroviruses (EV) deploy two proteases that mediate viral polyprotein cleavage and host
cell manipulation. Here, we report that EV 2A proteases cleave all three members of the …
cell manipulation. Here, we report that EV 2A proteases cleave all three members of the …
Zika virus production is resistant to RNase L antiviral activity
There is currently no knowledge of how the emerging human pathogen Zika virus (ZIKV)
interacts with the antiviral endoribonuclease L (RNase L) pathway during infection. Since …
interacts with the antiviral endoribonuclease L (RNase L) pathway during infection. Since …
eIF4G has intrinsic G-quadruplex binding activity that is required for tiRNA function
As cells encounter adverse environmental conditions, such as hypoxia, oxidative stress or
nutrient deprivation, they trigger stress response pathways to protect themselves until …
nutrient deprivation, they trigger stress response pathways to protect themselves until …
[HTML][HTML] A human cellular noncoding RNA activates the antiviral protein 2′–5′-oligoadenylate synthetase 1
BM Calderon, GL Conn - Journal of Biological Chemistry, 2018 - ASBMB
… D, kinetic analyses of OAS1 activation over a range of nc886 RNA concentrations. Data were
fit using nonlinear regression analysis to obtain the kinetic parameters V max and K app as …
fit using nonlinear regression analysis to obtain the kinetic parameters V max and K app as …