User profiles for D. Korkin
 | Dmitry KorkinJurist Dean's Professor of Computer Science, Worcester Polytechnic Institute Verified email at korkinlab.org Cited by 3506 |
A structural perspective on protein–protein interactions
… (d) Slice images and rendered surface of a ribosome-decorated portion of endoplasmic
reticulum [73]. In electron tomography, the specimen studied is progressively tilted upon an axis …
reticulum [73]. In electron tomography, the specimen studied is progressively tilted upon an axis …
Integrating diverse data for structure determination of macromolecular assemblies
To understand the cell, we need to determine the macromolecular assembly structures, which
may consist of tens to hundreds of components. First, we review the varied experimental …
may consist of tens to hundreds of components. First, we review the varied experimental …
A soybean cyst nematode resistance gene points to a new mechanism of plant resistance to pathogens
Soybean (Glycine max (L.) Merr.) is an important crop that provides a sustainable source of
protein and oil worldwide. Soybean cyst nematode (Heterodera glycines Ichinohe) is a …
protein and oil worldwide. Soybean cyst nematode (Heterodera glycines Ichinohe) is a …
[HTML][HTML] Structural genomics of SARS-CoV-2 indicates evolutionary conserved functional regions of viral proteins
During its first two and a half months, the recently emerged 2019 novel coronavirus, SARS-CoV-2,
has already infected over one-hundred thousand people worldwide and has taken …
has already infected over one-hundred thousand people worldwide and has taken …
Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection
… We observed that SARS-CoV-2 infection resulted in significant weight loss over 3 d in …
5E) at 3 d postinfection in animals treated with siRNA N_29293 or the cocktail. The lungs of …
5E) at 3 d postinfection in animals treated with siRNA N_29293 or the cocktail. The lungs of …
[HTML][HTML] Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism
… (d) Alternatively spliced isoforms of A2BP1 protein and their interaction partners. Primers
were designed to amplify the A2BP1 ORF that uses the downstream start site (CCDS10531) of …
were designed to amplify the A2BP1 ORF that uses the downstream start site (CCDS10531) of …
Dual roles for the variable domain in protein trafficking and host‐specific recognition of Heterodera glycines CLE effector proteins
J Wang, C Lee, A Replogle, S Joshi, D Korkin… - New …, 2010 - Wiley Online Library
… within 7 d after transplanting. Weak, primary roots grew between 2 and 8 cm within 7 d after
… the transgene, but exhibited wild-type root growth (9–16 cm within 7 d after transplanting). …
… the transgene, but exhibited wild-type root growth (9–16 cm within 7 d after transplanting). …
Community‐wide evaluation of methods for predicting the effect of mutations on protein–protein interactions
Community‐wide blind prediction experiments such as CAPRI and CASP provide an objective
measure of the current state of predictive methodology. Here we describe a community‐…
measure of the current state of predictive methodology. Here we describe a community‐…
[HTML][HTML] Determining effects of non-synonymous SNPs on protein-protein interactions using supervised and semi-supervised learning
… The polynomial kernel is then selected with d = 3 as the most accurate one, as it has the
highest f-measure value. SVM models are implemented using the libSVM package [56] and the …
highest f-measure value. SVM models are implemented using the libSVM package [56] and the …
The variation game: Cracking complex genetic disorders with NGS and omics data
Tremendous advances in Next Generation Sequencing (NGS) and high-throughput omics
methods have brought us one step closer towards mechanistic understanding of the complex …
methods have brought us one step closer towards mechanistic understanding of the complex …