… This means that k d 2 is much larger than k d 1 in our model. The result is that monomer
activation is much more pronounced (compare the solid to the dashed line in Figure 6a), and self…

We performed integrated genomic, transcriptomic, and proteomic profiling of 150 pancreatic
ductal adenocarcinoma (PDAC) specimens, including samples with characteristic low …

Diffuse large B cell lymphoma (DLBCL), the most common lymphoid malignancy in adults,
is a clinically and genetically heterogeneous disease that is further classified into …

… b–d Samples from Pat99 (b), Pat25 (c), and Pat272 (d) were stained with an antibody cocktail
for melanoma cells (mel.cocktail) using anti-melanosome (HMB45), anti-MART-1/melan A …

Whole-exome sequencing of cell-free DNA (cfDNA) could enable comprehensive profiling
of tumors from blood but the genome-wide concordance between cfDNA and tumor biopsies …

Cancer develops through a process of somatic evolution 1 , 2 . Sequencing data from a single
biopsy represent a snapshot of this process that can reveal the timing of specific genomic …

Biallelic inactivation of BRCA1 or BRCA2 is associated with a pattern of genome-wide mutations
known as signature 3. By analyzing ∼1,000 breast cancer samples, we confirmed this …

During cancer therapy, tumor heterogeneity can drive the evolution of multiple tumor
subclones harboring unique resistance mechanisms in an individual patient 1 , 2 – 3 . Previous …

INTRODUCTION Cancer genome studies have contributed to the analysis and discovery of
somatic mutations that drive cancer growth. However, studying the genetic makeup of a …

… To program the microrobot, we seek to identify one or more designs d from among the
space of possibilities that maximize the utility function u(d, y) as informed by the performance …