Introduction During vertebrate limb development, gene members of the HoxD cluster are
transcribed in two subsequent waves, following a collinear strategy. Early on, genes located in …

The spatial and temporal control of Hox gene transcription is essential for patterning the
vertebrate body axis. Although this process involves changes in histone posttranslational …

Developmental enhancers initiate transcription and are fundamental to our understanding
of developmental networks, evolution and disease. Despite their importance, the properties …

… d, Genomic tracks showing the differential γH2A ChIP–seq signal (log 2 [+DSB/−DSB])
before or after PDS5 … γH2AX foci were detected using method D in Colombus software. …

In contrast to most primary metabolism genes, the genes involved in secondary metabolism
and certain nutrient utilization pathways are clustered in fungi. Recently a nuclear protein, …

… D compartment, in agreement with our above data showing that D genes are not more
expressed than non-D … of DDR-upregulated D genes compared with those not targeted to the D …

Embryogenesis requires the precise activation and repression of many transcriptional
regulators. The Polycomb group proteins and the associated H3K27me3 histone mark are …

During development, expression of the Hoxa and Hoxd genes in zebrafish fins and mouse
limbs are regulated via a conserved chromatin structure. However, zebrafish lack certain …

Mammalian genomes contain numerous regulatory DNA sites with unknown target genes.
We used mice with an extra β-globin locus control region (LCR) to investigate how a regulator …

10.7554/eLife.02557.001 Hox genes are essential regulators of embryonic development.
Their step-wise transcriptional activation follows their genomic topology and the various states …