The Human Reference Atlas (HRA) aims to map all of the cells of the human body to advance
biomedical research and clinical practice. This Perspective presents collaborative work by …

Massive single-cell profiling efforts have accelerated our discovery of the cellular
composition of the human body while at the same time raising the need to formalize this new …

… (B–D) Summary statistics sharing by publication year for (B) GWA studies (C) publications and
in the Catalog overall (D… (B–D) Summary statistics sharing by publication year for (B) GWA …

For more than 100 years, the fruit fly Drosophila melanogaster has been one of the most
studied model organisms. Here, we present a single-cell atlas of the adult fly, Tabula …

The Human Phenotype Ontology (HPO)—a standardized vocabulary of phenotypic
abnormalities associated with 7000+ diseases—is used by thousands of researchers, clinicians, …

… Table 4 shows a summary of our current GO data for D. melanogaster. Although many of
the changes in GO annotation policy are quite recent, we can already see an improvement. …

Synapses are fundamental information-processing units of the brain, and synaptic dysregulation
is central to many brain disorders ("synaptopathies"). However, systematic annotation of …

Cells are fundamental function units of multicellular organisms, with different cell types
playing distinct physiological roles in the body. The recent advent of single-cell transcriptional …

Biological ontologies are used to organize, curate and interpret the vast quantities of data
arising from biological experiments. While this works well when using a single ontology, …

Despite a large and multifaceted effort to understand the vast landscape of phenotypic data,
their current form inhibits productive data analysis. The lack of a community-wide, consensus…