Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …

The Library of Integrated Network-Based Cellular Signatures (LINCS) is an NIH Common
Fund program that catalogs how human cells globally respond to chemical, genetic, and …

Directing the differentiation of induced pluripotent stem cells into motor neurons has allowed
investigators to develop new models of amyotrophic lateral sclerosis (ALS). However, …

To identify novel genes associated with ALS, we undertook two lines of investigation. We
carried out a genome-wide association study comparing 20,806 ALS cases and 59,804 controls…

… (D) Motor neuron survival over time was not altered in the iPSC-derived motor neuron cultures
derived from four individual C9ORF72 ALS (C9-ALS) patients versus four control subjects …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
the progressive loss of motor neurons. While several pathogenic mutations have been …

Purpose: Neuroblastoma is an aggressive childhood disease of the sympathetic nervous
system. Treatments are often ineffective and have serious side effects. Because resveratrol, a …

… C and D, cells were treated with DMSO control, 100 μM RES, 1 μM TG, 1 μM staurosporine
(STS), or exposed to 200 J/m 2 UV radiation, lysed, and caspase-2 (C) and caspase-8 (D) …

Spinal muscular atrophy (SMA) is a genetic disorder caused by a deletion of the survival
motor neuron 1 gene leading to motor neuron loss, muscle atrophy, paralysis, and death. We …

Through mechanisms that remain poorly defined, defects in nucleocytoplasmic transport and
accumulations of specific nuclear-pore-complex-associated proteins have been reported in …