… HA is a naturally occurring mucopolysaccharide composing of N-acetyl-d-glucosamine and
d-glucuronic acid, found in the extracellular tissue matrix of vertebrates. Dex is a bacterial-…

Genetic drugs based on nucleic acid biomolecules are a rapidly emerging class of medicines
that directly reprogramme the central dogma of biology to prevent and treat disease. …

Atom Transfer Radical Polymerization (ATRP) is an effective technique for the design and
preparation of multifunctional, nanostructured materials for a variety of applications in biology …

… d, Relative luciferase expression in each organ demonstrated that fractional expression
could be predictably tuned (0.1 mg kg −1 Luc mRNA, iv, 6 h). Data are shown as mean ± sem (n …

Lipid nanoparticles (LNPs) are a clinically mature technology for the delivery of genetic
medicines but have limited therapeutic applications due to liver accumulation. Recently, our …

… d H&E and Ki67 staining further confirmed progressive tumor formation. Higher tumor
proliferation biomarker Ki67 expression was detected in tumor lesions. Scale bar = 100 μm. …

… (D) Microwave irradiation of epoxides and dipeptides dramatically reduced the reaction
time from 3 d to 5 h. Reactions between lysine–lysine and poly-l-lysine and aldehydes and …

… , Representative 3D construction of immunofluorescence (c) and 3D surface plot of
quantification (d) of collagen I and YAP in fixed tumour tissues after 30 d therapy of mice by weekly …

… D) Surveyor confirmed editing of the luciferase target at mRNA:sgRNA ratios of 3:1 or higher
… the Surveyor assay (Figure 4 D), while control ZNPs did not show any editing (Figure S21). …

… d, A list of 28 amines and 13 alkylated dioxaphospholane oxide molecules used for iPhos
… d, mRNA expression in spleen by iPhos with different alkyl chain length at phosphate group …