Prostate tumours are highly variable in their response to therapies, but clinically available
prognostic factors can explain only a fraction of this heterogeneity. Here we analysed 200 …

Herein we provide a detailed molecular analysis of the spatial heterogeneity of clinically
localized, multifocal prostate cancer to delineate new oncogenes or tumor suppressors. We …

The ability to measure physical activity through wrist-worn devices provides an opportunity for
cardiovascular medicine. However, the accuracy of commercial devices is largely unknown…

OBJECTIVE Despite extensive evidence for genetic susceptibility to diabetic nephropathy,
the identification of susceptibility genes and their variants has had limited success. To search …

The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a
heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac …

The detection of somatic mutations from cancer genome sequences is key to understanding
the genetic basis of disease progression, patient survival and response to therapy. …

Diabetic kidney disease, or diabetic nephropathy (DN), is a major complication of diabetes
and the leading cause of end-stage renal disease (ESRD) that requires dialysis treatment or …

Purpose Current clinical genomics assays primarily utilize short-read sequencing (SRS),
but SRS has limited ability to evaluate repetitive regions and structural variants. Long-read …

Motivation: The NanoString nCounter Platform is a new and promising technology for
measuring nucleic acid abundances. It has several advantages over PCR-based techniques, …

Polymorphous low-grade adenocarcinoma (PLGA) is the second most frequent type of malignant
tumor of the minor salivary glands. We identified PRKD1 hotspot mutations encoding p.…