An effective immune response against viral infections depends on the activation of cytotoxic
T cells that can clear infection by killing virus-infected cells. Proper activation of these T cells …

… Supplementary file D provides an overview of the outcomes from the quality/risk of bias-…
More detailed features of the studies and their limitations are stated in Supplementary file D. …

In the past decade, evidence has accumulated that human immunodeficiency virus (HIV)-induced
chronic immune activation drives progression to AIDS. Studies among different …

Background The Ad26.COV2.S vaccine, which was approved as a single-shot immunization
regimen, has been shown to be effective against severe coronavirus disease 2019. …

The ability to decode antigen specificities encapsulated in the sequences of rearranged T-cell
receptor (TCR) genes is critical for our understanding of the adaptive immune system and …

… Therefore, to test for non-inferiority, we decided that the anticipated true response rates in
cohorts B, C, and D all had to be equal to the observed true response rate in cohort A (ie, 100%…

The early-life microbiome appears to be affected by mode of delivery, but this effect may
depend on intrapartum antibiotic exposure. Here, we assess the effect of delivery mode on gut …

… (d) The majority of CD8 on γδT cells of congenitally infected newborns is composed of
the CD8αα homodimer. Percentages of CD8+ γδT cells and CD8+ αβT cells … D van Baarle …

Background. In kidney patients COVID-19 is associated with severely increased morbidity
and mortality. A comprehensive comparison of the immunogenicity, tolerability, and safety of …

Background An urgent need exists to improve the suboptimal COVID-19 vaccine response
in kidney transplant recipients (KTRs). We aimed to compare three alternative strategies with …