The Rho family of GTPases (members of the Ras superfamily) are best known for their roles
in regulating cytoskeletal dynamics. It is also well established that misregulation of Rho …

Small GTPases of the Ras superfamily are key regulators of diverse cellular and developmental
events, including differentiation, cell division, vesicle transport, nuclear assembly, and …

The Caenorhabditis elegans genome contains three rac-like genes, ced-10, mig-2, and rac-2.
We report that ced-10, mig-2 and rac-2 act redundantly in axon pathfinding: inactivating …

Netrins promote axon outgrowth and turning through DCC/UNC-40 receptors. To characterize
Netrin signaling, we generated a gain-of-function UNC-40 molecule, MYR::UNC-40. MYR::…

Mutation in the Caenorhabditis elegans gene osm-6 was previously shown to result in defects
in the ultrastructure of sensory cilia and defects in chemosensory and mechanosensory …

… elegans Rac double mutants (EA Lundquist, unpublished data). These studies of loss of Rac
function indicate that Racs are required for axon guidance, outgrowth and branch formation…

… unc-73 acts with the three Racs in CAN and D-class axon development (Lundquist et al.,2001),
and here we find that unc-73 also affects PDE axon development. The incomplete loss-of-…

… The authors wish to thank members of the Lundquist and Ackley labs for helpful discussion,
JK Alan for help with 3T3 cell culture, TC Gamblin for use of the Varian Cary Eclipse …

Mutations in the mec-8 gene of Caenorhabditis elegans were previously shown to affect the
functions of body wall muscle and mechanosensory and chemosensory neurons. Mutations …

Background While many molecules involved in axon guidance have been identified, the
cellular and molecular mechanisms by which these molecules regulate growth cone …