User profiles for E. A. Morrison
Emma A. MorrisonAssistant Professor of Biochemistry, Medical College of Wisconsin Verified email at mcw.edu Cited by 832 |
[HTML][HTML] Reading more than histones: the prevalence of nucleic acid binding among reader domains
The eukaryotic genome is packaged into the cell nucleus in the form of chromatin, a complex
of genomic DNA and histone proteins. Chromatin structure regulation is critical for all DNA …
of genomic DNA and histone proteins. Chromatin structure regulation is critical for all DNA …
Antiparallel EmrE exports drugs by exchanging between asymmetric structures
Small multidrug resistance transporters provide an ideal system to study the minimal
requirements for active transport. EmrE is one such transporter in Escherichia coli. It exports a …
requirements for active transport. EmrE is one such transporter in Escherichia coli. It exports a …
The conformation of the histone H3 tail inhibits association of the BPTF PHD finger with the nucleosome
10.7554/eLife.31481.001 Histone tails harbor a plethora of post-translational modifications
that direct the function of chromatin regulators, which recognize them through effector …
that direct the function of chromatin regulators, which recognize them through effector …
[HTML][HTML] DNA binding drives the association of BRG1/hBRM bromodomains with nucleosomes
EA Morrison, JC Sanchez, JL Ronan, DP Farrell… - Nature …, 2017 - nature.com
BRG1 and BRM, central components of the BAF (mSWI/SNF) chromatin remodelling
complex, are critical in chromatin structure regulation. Here, we show that the human BRM (hBRM) …
complex, are critical in chromatin structure regulation. Here, we show that the human BRM (hBRM) …
[HTML][HTML] Reconstitution of integral membrane proteins into isotropic bicelles with improved sample stability and expanded lipid composition profile
EA Morrison, KA Henzler-Wildman - Biochimica et Biophysica Acta (BBA) …, 2012 - Elsevier
Reconstitution of integral membrane proteins into membrane mimetic environments suitable
for biophysical and structural studies has long been a challenge. Isotropic bicelles promise …
for biophysical and structural studies has long been a challenge. Isotropic bicelles promise …
New free-exchange model of EmrE transport
…, NE Thomas, EA Morrison… - Proceedings of the …, 2017 - National Acad Sciences
EmrE is a small multidrug resistance transporter found in Escherichia coli that confers resistance
to toxic polyaromatic cations due to its proton-coupled antiport of these substrates. Here …
to toxic polyaromatic cations due to its proton-coupled antiport of these substrates. Here …
Diagonal earlobe creases and fatal cardiovascular disease: a necropsy study.
N Kirkham, T Murrells, DH Melcher, EA Morrison - Heart, 1989 - heart.bmj.com
The association between diagonal earlobe creases and fatal cardiovascular disease was
investigated in a consecutive series of 303 coroner's necropsies. Those studied all died …
investigated in a consecutive series of 303 coroner's necropsies. Those studied all died …
Nucleosome composition regulates the histone H3 tail conformational ensemble and accessibility
Hexasomes and tetrasomes are intermediates in nucleosome assembly and disassembly.
Their formation is promoted by histone chaperones, ATP-dependent remodelers, and RNA …
Their formation is promoted by histone chaperones, ATP-dependent remodelers, and RNA …
Asymmetric protonation of EmrE
EA Morrison, AE Robinson, Y Liu… - Journal of General …, 2015 - rupress.org
The small multidrug resistance transporter EmrE is a homodimer that uses energy provided
by the proton motive force to drive the efflux of drug substrates. The pKa values of its “active-…
by the proton motive force to drive the efflux of drug substrates. The pKa values of its “active-…
[HTML][HTML] Transported substrate determines exchange rate in the multidrug resistance transporter EmrE
EA Morrison, KA Henzler-Wildman - Journal of Biological Chemistry, 2014 - ASBMB
EmrE, a small multidrug resistance transporter, serves as an ideal model to study coupling
between multidrug recognition and protein function. EmrE has a single small binding pocket …
between multidrug recognition and protein function. EmrE has a single small binding pocket …