User profiles for E. A. Morrison

Emma A. Morrison

Assistant Professor of Biochemistry, Medical College of Wisconsin
Verified email at mcw.edu
Cited by 832

[HTML][HTML] Reading more than histones: the prevalence of nucleic acid binding among reader domains

TM Weaver, EA Morrison, CA Musselman - Molecules, 2018 - mdpi.com
The eukaryotic genome is packaged into the cell nucleus in the form of chromatin, a complex
of genomic DNA and histone proteins. Chromatin structure regulation is critical for all DNA …

Antiparallel EmrE exports drugs by exchanging between asymmetric structures

EA Morrison, GT DeKoster, S Dutta, R Vafabakhsh… - Nature, 2012 - nature.com
Small multidrug resistance transporters provide an ideal system to study the minimal
requirements for active transport. EmrE is one such transporter in Escherichia coli. It exports a …

The conformation of the histone H3 tail inhibits association of the BPTF PHD finger with the nucleosome

EA Morrison, S Bowerman, KL Sylvers… - Elife, 2018 - elifesciences.org
10.7554/eLife.31481.001 Histone tails harbor a plethora of post-translational modifications
that direct the function of chromatin regulators, which recognize them through effector …

[HTML][HTML] DNA binding drives the association of BRG1/hBRM bromodomains with nucleosomes

EA Morrison, JC Sanchez, JL Ronan, DP Farrell… - Nature …, 2017 - nature.com
BRG1 and BRM, central components of the BAF (mSWI/SNF) chromatin remodelling
complex, are critical in chromatin structure regulation. Here, we show that the human BRM (hBRM) …

[HTML][HTML] Reconstitution of integral membrane proteins into isotropic bicelles with improved sample stability and expanded lipid composition profile

EA Morrison, KA Henzler-Wildman - Biochimica et Biophysica Acta (BBA) …, 2012 - Elsevier
Reconstitution of integral membrane proteins into membrane mimetic environments suitable
for biophysical and structural studies has long been a challenge. Isotropic bicelles promise …

New free-exchange model of EmrE transport

…, NE Thomas, EA Morrison… - Proceedings of the …, 2017 - National Acad Sciences
EmrE is a small multidrug resistance transporter found in Escherichia coli that confers resistance
to toxic polyaromatic cations due to its proton-coupled antiport of these substrates. Here …

Diagonal earlobe creases and fatal cardiovascular disease: a necropsy study.

N Kirkham, T Murrells, DH Melcher, EA Morrison - Heart, 1989 - heart.bmj.com
The association between diagonal earlobe creases and fatal cardiovascular disease was
investigated in a consecutive series of 303 coroner's necropsies. Those studied all died …

Nucleosome composition regulates the histone H3 tail conformational ensemble and accessibility

EA Morrison, L Baweja, MG Poirier… - Nucleic acids …, 2021 - academic.oup.com
Hexasomes and tetrasomes are intermediates in nucleosome assembly and disassembly.
Their formation is promoted by histone chaperones, ATP-dependent remodelers, and RNA …

Asymmetric protonation of EmrE

EA Morrison, AE Robinson, Y Liu… - Journal of General …, 2015 - rupress.org
The small multidrug resistance transporter EmrE is a homodimer that uses energy provided
by the proton motive force to drive the efflux of drug substrates. The pKa values of its “active-…

[HTML][HTML] Transported substrate determines exchange rate in the multidrug resistance transporter EmrE

EA Morrison, KA Henzler-Wildman - Journal of Biological Chemistry, 2014 - ASBMB
EmrE, a small multidrug resistance transporter, serves as an ideal model to study coupling
between multidrug recognition and protein function. EmrE has a single small binding pocket …