User profiles for E. K. Karlsson

Elinor K. Karlsson

University of Massachusetts Medical School & Broad Institute
Verified email at broadinstitute.org
Cited by 24694

Genome sequence, comparative analysis and haplotype structure of the domestic dog

K Lindblad-Toh, CM Wade, TS Mikkelsen, EK Karlsson… - Nature, 2005 - nature.com
Here we report a high-quality draft genome sequence of the domestic dog (Canis familiaris),
together with a dense map of single nucleotide polymorphisms (SNPs) across breeds. The …

[HTML][HTML] Genomic maps and comparative analysis of histone modifications in human and mouse

…, DK Bailey, DJ Huebert, S McMahon, EK Karlsson… - Cell, 2005 - cell.com
We mapped histone H3 lysine 4 di- and trimethylation and lysine 9/14 acetylation across the
nonrepetitive portions of human chromosomes 21 and 22 and compared patterns of lysine 4 …

[HTML][HTML] Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans

…, AME Jones, JDG Jones, RW Jones, EK Karlsson… - Nature, 2009 - nature.com
Phytophthora infestans is the most destructive pathogen of potato and a model organism for
the oomycetes, a distinct lineage of fungus-like eukaryotes that are related to organisms …

Efficient mapping of mendelian traits in dogs through genome-wide association

EK Karlsson, I Baranowska, CM Wade… - Nature …, 2007 - nature.com
With several hundred genetic diseases and an advantageous genome structure, dogs are
ideal for mapping genes that cause disease. Here we report the development of a genotyping …

Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates

…, EC Teeling, EK Karlsson… - Proceedings of the …, 2020 - National Acad Sciences
The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the
cause of COVID-19. The main receptor of SARS-CoV-2, angiotensin I converting enzyme 2 …

Rethinking dog domestication by integrating genetics, archeology, and biogeography

G Larson, EK Karlsson, A Perri… - Proceedings of the …, 2012 - National Acad Sciences
The dog was the first domesticated animal but it remains uncertain when the domestication
process began and whether it occurred just once or multiple times across the Northern …

Genomic targets of nuclear estrogen receptors

R O'Lone, MC Frith, EK Karlsson… - Molecular …, 2004 - academic.oup.com
Estrogen influences the physiology of many target tissues in both women and men. The long-term
effects of estrogen are mediated predominantly by nuclear estrogen receptors (ERs) …

A composite of multiple signals distinguishes causal variants in regions of positive selection

SR Grossman, I Shylakhter, EK Karlsson, EH Byrne… - Science, 2010 - science.org
The human genome contains hundreds of regions whose patterns of genetic variation indicate
recent positive natural selection, yet for most the underlying gene and the advantageous …

The earth BioGenome project 2020: Starting the clock

…, SJM Jones, EK Karlsson… - Proceedings of the …, 2022 - National Acad Sciences
November 2020 marked 2 y since the launch of the Earth BioGenome Project (EBP), which
aims to sequence all known eukaryotic species in a 10-y timeframe. Since then, significant …

[HTML][HTML] Natural selection and infectious disease in human populations

EK Karlsson, DP Kwiatkowski, PC Sabeti - Nature Reviews Genetics, 2014 - nature.com
The ancient biological 'arms race' between microbial pathogens and humans has shaped
genetic variation in modern populations, and this has important implications for the growing …