The vast majority of coding variants are rare, and assessment of the contribution of rare
variants to complex traits is hampered by low statistical power and limited functional data. …

Myocardial infarction (MI), a leading cause of death around the world, displays a complex
pattern of inheritance 1 , 2 . When MI occurs early in life, genetic inheritance is a major …

Background Family history is a significant risk factor for prostate cancer, although the
molecular basis for this association is poorly understood. Linkage studies have implicated …

Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed
countries. To identify common PrCa susceptibility alleles, we previously conducted a genome-…

Deletions on human chromosome 8p22–23 in prostate cancer cells 1 and linkage studies in
families affected with hereditary prostate cancer (HPC) 2, 3, 4 have implicated this region in …

… Author Affiliations: Cystic Fibrosis/Pulmonary Research and Treatment Center (Drs Bartlett
and Knowles, Ms Pace, and Mr Hannah) and Department of Genetics (Mr Wang and Dr Lange…

… Lange and E. Lange) and Biostatistics (Drs E. … Lange had full access to all of the data in the
study and takes responsibility for the integrity of the data and the accuracy of the data analysis…

Elevated low-density lipoprotein cholesterol (LDL-C) is a treatable, heritable risk factor for
cardiovascular disease. Genome-wide association studies (GWASs) have identified 157 …

Chronic periodontitis (CP) is a common oral disease that confers substantial systemic
inflammatory and microbial burden and is a major cause of tooth loss. Here, we present the results …

A combined genome-wide association and linkage study was used to identify loci causing
variation in cystic fibrosis lung disease severity. We identified a significant association (P = …