COPD is a heterogeneous syndrome. Many COPD subtypes have been proposed, but there
is not yet consensus on how many COPD subtypes there are and how they should be …

… (D and E) Frequency of non-hypermutated (D) and hypermutated (E) HIV-1 RNA in resting
… We did not observe significant CTL recognition of the mutated 19B3 clone (Figure 5E), …

Background Eosinophilic airway inflammation in patients with chronic obstructive pulmonary
disease (COPD) is associated with exacerbations and responsivity to steroids, suggesting …

Background Chronic bronchitis (CB) increases risk of COPD exacerbations. We have shown
that the St. George’s Respiratory Questionnaire (SGRQ) CB definition identifies patients …

Rationale: Emphysema has considerable variability in the severity and distribution of parenchymal
destruction throughout the lungs. Upper lobe–predominant emphysema has emerged …

Background Emphysema has considerable variability in its regional distribution. Craniocaudal
emphysema distribution is an important predictor of the response to lung volume reduction…

The progression of chronic obstructive pulmonary disease (COPD) is associated with
marked alterations in circulating immune cell populations, but no studies have characterized …

Smoking causes chronic obstructive pulmonary disease (COPD). Though recent studies
identified a COPD metabolomic signature in blood, no large studies examine the metabolome in …

Background: Small studies have recently suggested that there are specific plasma metabolic
signatures in chronic obstructive pulmonary disease (COPD), but there have been no large …

Context Fracture risk in people with type 1 diabetes (T1D) is higher than their peers without
diabetes. Objective To compare bone mineral density (BMD) across the lifespan in …