This meta-analysis examined 118 studies of the psychosocial outcomes of children exposed
to interparental violence. Correlational studies showed a significant association between …

A primary goal of human genetics is to identify DNA sequence variants that influence
biomedical traits, particularly those related to the onset and progression of human disease. Over …

Personalized medicine has largely been enabled by the integration of genomic and other data
with electronic health records (EHRs) in the United States and elsewhere. Increased EHR …

… We also thank E. Lander, N. Patterson and members of the Medical and Population
Genetics group at the Broad Institute of Harvard and Massachusetts Institute of Technology for …

As a first step toward understanding how rare variants contribute to risk for complex diseases,
we sequenced 15,585 human protein-coding genes to an average median depth of 111× …

The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate the genetic
architecture and biology of heart, lung, blood and sleep disorders, with the ultimate goal of …

Here the Human Pangenome Reference Consortium presents a first draft of the human
pangenome reference. The pangenome contains 47 phased, diploid assemblies from a cohort of …

The vast majority of genome-wide association studies (GWASs) are performed in Europeans,
and their transferability to other populations is dependent on many factors (eg, linkage …

Age is the dominant risk factor for most chronic human diseases, but the mechanisms
through which ageing confers this risk are largely unknown 1 . The age-related acquisition of …

Genome-wide association studies (GWAS) have laid the foundation for investigations into the
biology of complex traits, drug development and clinical guidelines. However, the majority …