User profiles for E. Lein
Ed LeinInvestigator, Director Human Cell Types Program, Allen Institute for Brain Science Verified email at alleninstitute.org Cited by 42781 |
Functional organization of the hippocampal longitudinal axis
BA Strange, MP Witter, ES Lein, EI Moser - Nature reviews …, 2014 - nature.com
The precise functional role of the hippocampus remains a topic of much debate. The dominant
view is that the dorsal (or posterior) hippocampus is implicated in memory and spatial …
view is that the dorsal (or posterior) hippocampus is implicated in memory and spatial …
The promise of spatial transcriptomics for neuroscience in the era of molecular cell typing
The stereotyped spatial architecture of the brain is both beautiful and fundamentally related
to its function, extending from gross morphology to individual neuron types, where soma …
to its function, extending from gross morphology to individual neuron types, where soma …
[HTML][HTML] A community-based transcriptomics classification and nomenclature of neocortical cell types
To understand the function of cortical circuits, it is necessary to catalog their cellular diversity.
Past attempts to do so using anatomical, physiological or molecular features of cortical …
Past attempts to do so using anatomical, physiological or molecular features of cortical …
Genome-wide atlas of gene expression in the adult mouse brain
ES Lein, MJ Hawrylycz, N Ao, M Ayres, A Bensinger… - Nature, 2007 - nature.com
Molecular approaches to understanding the functional circuitry of the nervous system
promise new insights into the relationship between genes, brain and behaviour. The cellular …
promise new insights into the relationship between genes, brain and behaviour. The cellular …
An anatomically comprehensive atlas of the adult human brain transcriptome
MJ Hawrylycz, ES Lein, AL Guillozet-Bongaarts… - Nature, 2012 - nature.com
Neuroanatomically precise, genome-wide maps of transcript distributions are critical resources
to complement genomic sequence data and to correlate functional and genetic brain …
to complement genomic sequence data and to correlate functional and genetic brain …
A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
…, RD Palmiter, MJ Hawrylycz, AR Jones, ES Lein… - Nature …, 2010 - nature.com
The Cre/lox system is widely used in mice to achieve cell-type-specific gene expression.
However, a strong and universally responding system to express genes under Cre control is still …
However, a strong and universally responding system to express genes under Cre control is still …
The human cell atlas
10.7554/eLife.27041.001 The recent advent of methods for high-throughput single-cell
molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe …
molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe …
The complete genome sequence of a Neanderthal from the Altai Mountains
We present a high-quality genome sequence of a Neanderthal woman from Siberia. We
show that her parents were related at the level of half-siblings and that mating among close …
show that her parents were related at the level of half-siblings and that mating among close …
[HTML][HTML] Shared and distinct transcriptomic cell types across neocortical areas
The neocortex contains a multitude of cell types that are segregated into layers and functionally
distinct areas. To investigate the diversity of cell types across the mouse neocortex, here …
distinct areas. To investigate the diversity of cell types across the mouse neocortex, here …
Wnt signalling regulates adult hippocampal neurogenesis
The generation of new neurons from neural stem cells is restricted to two regions of the adult
mammalian central nervous system: the subventricular zone of the lateral ventricle, and the …
mammalian central nervous system: the subventricular zone of the lateral ventricle, and the …