User profiles for E. Mahen

Edo Mahendra

United Nations
Verified email at un.org
Cited by 499

[HTML][HTML] p53 regulates cell cycle and microRNAs to promote differentiation of human embryonic stem cells

AK Jain, K Allton, M Iacovino, E Mahen… - PLoS …, 2012 - journals.plos.org
Multiple studies show that tumor suppressor p53 is a barrier to dedifferentiation; whether this
is strictly due to repression of proliferation remains a subject of debate. Here, we show that …

Inducible cassette exchange: a rapid and efficient system enabling conditional gene expression in embryonic stem and primary cells

…, D Bosnakovski, H Fey, D Rux, G Bajwa, E Mahen… - Stem …, 2011 - academic.oup.com
Genetic modification is critically enabling for studies addressing specification and
maintenance of cell fate; however, methods for engineering modifications are inefficient. We …

[HTML][HTML] mRNA secondary structures fold sequentially but exchange rapidly in vivo

EM Mahen, PY Watson, JW Cottrell, MJ Fedor - PLoS biology, 2010 - journals.plos.org
… (B–E) Ribozymes with the potential to form alternative nonfunctional secondary structures, …
that have greater thermodynamic stability (C and E) is consistent with sequential folding of …

[PDF][PDF] Metabolic control over mTOR-dependent diapause-like state

…, DC Jones, C Cavanaugh, JW Miklas, E Mahen… - Developmental cell, 2020 - cell.com
… (E) PCA plot using transcript splicing rate of our RNA-sequence samples clearly separates
diapause and pre-/post-implantation samples. (F) Sashimi plot of Lkb1 exons 8–10. Bar …

International migration: Trends, determinants, and policy effects

…, M Czaika, ML Flahaux, E Mahendra… - Population and …, 2019 - Wiley Online Library
… (where migration costs are much higher) (Mahendra 2014a). This is in line with evidence …
to acquire such services privately through remittances (Mahendra forthcoming). In central and …

NLRP7 affects trophoblast lineage differentiation, binds to overexpressed YY1 and alters CpG methylation

…, S Otta, Z Liu, M Iacovino, EM Mahen… - Human molecular …, 2014 - academic.oup.com
… (E) HEK293 cells were transfected with transfection agent alone (1), pDESTV5 (2), pDESTmyc
(3), NLRP7-V5 (4), myc-YY1 (5) and NLRP7-V5 together with myc-YY1 (6). Whole-cell …

Kinesin Spindle Protein (KSP) Inhibitors. 9. Discovery of (2S)-4-(2,5-Difluorophenyl)-N-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5 …

…, C Li, DE Slaughter, E Mahan… - Journal of medicinal …, 2008 - ACS Publications
Inhibition of kinesin spindle protein (KSP) is a novel mechanism for treatment of cancer with
the potential to overcome limitations associated with currently employed cytotoxic agents. …

[HTML][HTML] Guidance for the practical management of the direct oral anticoagulants (DOACs) in VTE treatment

AE Burnett, CE Mahan, SR Vazquez, LB Oertel… - Journal of thrombosis …, 2016 - Springer
Venous thromboembolism (VTE) is a serious medical condition associated with significant
morbidity and mortality, and an incidence that is expected to double in the next forty years. …

Hydraamphiphiles: novel linear dendritic block copolymer surfactants

TM Chapman, GL Hillyer, EJ Mahan… - Journal of the American …, 1994 - ACS Publications
We report the preparation of polymeric surfactants with hydrophobic terminal residues on a
dendrimer attached to a hydrophilic tail of poly (ethylene oxide)(PEO). The latter also serves …

[PDF][PDF] Kinetics and thermodynamics make different contributions to RNA folding in vitro and in yeast

EM Mahen, JW Harger, EM Calderon, MJ Fedor - Molecular cell, 2005 - cell.com
… Plasmids were propagated in E. coli … a high free Mg2+ that self-splice rapidly or not at all in
E. coli, arguing … Berkhout, B., Ooms, M., Beerens, N., Huthoff, H., Southern, E., and mixed with …