User profiles for E. Marcora
 | Edoardo MarcoraIcahn School of Medicine at Mount Sinai Verified email at mssm.edu Cited by 2927 |
[HTML][HTML] The complex genetic architecture of Alzheimer's disease: novel insights and future directions
…, B Fulton-Howard, A Podlesny-Drabiniok, E Marcora… - …, 2023 - thelancet.com
Background Alzheimer's disease (AD) is a complex multifactorial neurodegenerative disorder
and the most common form of dementia. AD is highly heritable, with heritability estimates …
and the most common form of dementia. AD is highly heritable, with heritability estimates …
Microglial efferocytosis: diving into the Alzheimer's disease gene pool
… Andrews,1,2,3 Edoardo Marcora,1,2,* and Alison M. Goate1,2,* 1Ronald M. Loeb Center for
Alzheimer’s Disease, 1 … For example, Apolipoprotein E (APOE) is a major risk gene for both …
Alzheimer’s Disease, 1 … For example, Apolipoprotein E (APOE) is a major risk gene for both …
Microglial phagocytosis: a disease-associated process emerging from Alzheimer's disease genetics
… By far the strongest genetic risk factor for LOAD is the apolipoprotein E (APOE) genotype.
There are three isoforms of APOE: APOE2, APOE3, and APOE4. The APOE33 genotype (…
There are three isoforms of APOE: APOE2, APOE3, and APOE4. The APOE33 genotype (…
[PDF][PDF] Cholesterol and matrisome pathways dysregulated in astrocytes and microglia
The impact of apolipoprotein E ε4 (APOE4), the strongest genetic risk factor for Alzheimer's
disease (AD), on human brain cellular function remains unclear. Here, we investigated the …
disease (AD), on human brain cellular function remains unclear. Here, we investigated the …
[HTML][HTML] Risk prediction of late-onset Alzheimer's disease implies an oligogenic architecture
Genetic association studies have identified 44 common genome-wide significant risk loci for
late-onset Alzheimer’s disease (LOAD). However, LOAD genetic architecture and prediction …
late-onset Alzheimer’s disease (LOAD). However, LOAD genetic architecture and prediction …
[HTML][HTML] Integration of Alzheimer's disease genetics and myeloid genomics identifies disease risk regulatory elements and genes
… e Allelic imbalance of chromatin accessibility at the rs636317 site is observed in the brain.
Each pair of dots connected by a grey line represent an individual. The protective allele (C) …
Each pair of dots connected by a grey line represent an individual. The protective allele (C) …
A common haplotype lowers PU. 1 expression in myeloid cells and delays onset of Alzheimer's disease
A genome-wide survival analysis of 14,406 Alzheimer's disease (AD) cases and 25,849
controls identified eight previously reported AD risk loci and 14 novel loci associated with age at …
controls identified eight previously reported AD risk loci and 14 novel loci associated with age at …
[HTML][HTML] Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional …
The Alzheimer’s Disease Sequencing Project (ADSP) undertook whole exome sequencing
in 5,740 late-onset Alzheimer disease (AD) cases and 5,096 cognitively normal controls …
in 5,740 late-onset Alzheimer disease (AD) cases and 5,096 cognitively normal controls …
[HTML][HTML] The variant call format provides efficient and robust storage of GWAS summary statistics
GWAS summary statistics are fundamental for a variety of research applications yet no
common storage format has been widely adopted. Existing tabular formats ambiguously or …
common storage format has been widely adopted. Existing tabular formats ambiguously or …
Causal associations between modifiable risk factors and the Alzheimer's phenome
Objective The purpose of this study was to infer causal relationships between 22 previously
reported risk factors for Alzheimer's disease (AD) and the “AD phenome”: AD, AD age of …
reported risk factors for Alzheimer's disease (AD) and the “AD phenome”: AD, AD age of …