Validation of multi-gene biomarkers for clinical outcomes is one of the most important issues
for cancer prognosis. An important source of information for virtual validation is the high …

We leveraged IDH wild-type glioblastomas, derivative neurospheres, and single-cell gene
expression profiles to define three tumor-intrinsic transcriptional subtypes designated as …

Cancer cells survive cellular crisis through telomere maintenance mechanisms. We report
telomere lengths in 18,430 samples, including tumors and non-neoplastic samples, across 31 …

Gene fusion represents a class of molecular aberrations in cancer and has been exploited
for therapeutic purposes. In this paper we describe TumorFusions, a data portal that …

In the originally published version of this paper’s Supplemental Information, incorrect
headers were used for the gene signatures listed in Table S1. Specifically, the headers of the …

Cancer types are commonly classified by histopathology and more recently through
molecular characteristics such as gene expression, mutations, copy number variations and …

The extent and nature of epigenomic changes associated with melanoma progression is poorly
understood. Through systematic epigenomic profiling of 35 epigenetic modifications and …

Background. Co-deletion of 1p and 19q marks a diffuse glioma subtype associated with
relatively favorable overall survival; however, heterogeneous clinical outcomes are observed …

Sporadic gliomas in companion dogs provide a window on the interaction between
tumorigenic mechanisms and host environment. We compared the molecular profiles of canine …

Purpose: Exploration of novel strategies to extend the benefit of PARP inhibitors beyond
BRCA-mutant cancers is of great interest in personalized medicine. Here, we identified EGFR …