Staphylococcus aureus is an opportunistic human pathogen, which is a leading cause of
infections worldwide. The challenge in treating S. aureus infection is linked to the development …

A synergistic combination of two next-generation sequencing platforms with a detailed
comparative BAC physical contig map provided a cost-effective assembly of the genome …

We present a fast mapping-based algorithm to compute the mappability of each region of a
reference genome up to a specified number of mismatches. Knowing the mappability of a …

As whole-genome sequencing for cancer genome analysis becomes a clinical tool, a full
understanding of the variables affecting sequencing analysis output is required. Here using …

To understand basic principles of bacterial metabolism organization and regulation, but
also the impact of genome size, we systematically studied one of the smallest bacteria, …

We analyzed the DNA methylome of ten subpopulations spanning the entire B cell differentiation
program by whole-genome bisulfite sequencing and high-density microarrays. We …

… by the Alon group; this has been achieved for 2,000 different promoters in E. coli, giving an
unprecedented look at E. coli promoter activity 17 . GFP fluorescence dynamics show distinct …

… of the primary library then get amplified by in silico PCR ( D )—optionally after selecting a
certain size range—and the final library then is subjected to simulated sequencing ( E ), …

While analyzing the DNA methylome of multiple myeloma (MM), a plasma cell neoplasm, by
whole-genome bisulfite sequencing and high-density arrays, we observed a highly …

We analyzed the in silico purified DNA methylation signatures of 82 mantle cell lymphomas (MCL)
in comparison with cell subpopulations spanning the entire B cell lineage. We …