[HTML][HTML] Falls in young, middle-aged and older community dwelling adults: perceived cause, environmental factors and injury

LA Talbot, RJ Musiol, EK Witham, EJ Metter - BMC public health, 2005 - Springer
Background Falls in older people have been characterized extensively in the literature,
however little has been reported regarding falls in middle-aged and younger adults. The …

[HTML][HTML] A tachykinin-like neuroendocrine signalling axis couples central serotonin action and nutrient sensing with peripheral lipid metabolism

L Palamiuc, T Noble, E Witham, H Ratanpal… - Nature …, 2017 - nature.com
… (e) Individual values for the fluorescence intensity of CLM::GFP within a single coelomocyte
are shown for each condition. Bars indicate the average value±sem within each condition. …

Cardiac-restricted angiotensin-converting enzyme overexpression causes conduction defects and connexin dysregulation

…, S Iravanian, J Langberg, EA Witham… - American Journal …, 2007 - journals.physiology.org
Renin-angiotensin (RAS) system activation is associated with an increased risk of sudden
death. Previously, we used cardiac-restricted angiotensin-converting enzyme (ACE) …

Prenatal exposure to low levels of androgen accelerates female puberty onset and reproductive senescence in mice

EA Witham, JD Meadows, S Shojaei… - …, 2012 - academic.oup.com
… In females, the ovaries produce testosterone (T), which is aromatized by follicle-derived
aromatase into estradiol (E 2 ) (1). E 2 and T exert feedback effects (E 2 , positive and negative; T…

Kisspeptin regulates gonadotropin genes via immediate early gene induction in pituitary gonadotropes

EA Witham, JD Meadows, HM Hoffmann… - Molecular …, 2013 - academic.oup.com
… Our finding that pituitary Kiss1r was increased during the LH surge in OVX+E females
provides a physiologic context for furthering the understanding of kisspeptin's role in the pituitary. …

[PDF][PDF] C. elegans body cavity neurons are homeostatic sensors that integrate fluctuations in oxygen availability and internal nutrient reserves

E Witham, C Comunian, H Ratanpal, S Skora… - Cell reports, 2016 - cell.com
… (E) Fluorescent image of a transgenic animal bearing a gpa-8::GFP transgene. Blue
arrowheads indicate expression in AQR and PQR neurons, and the white arrowhead indicates …

Inhibition of renin-angiotensin system (RAS) reduces ventricular tachycardia risk by altering connexin43

…, E Dolmatova, Z Jiao, BS Harris, EA Witham… - Journal of Molecular …, 2011 - Springer
Renin-angiotensin system (RAS) activation is associated with arrhythmias. We investigated
the effects of RAS inhibition in cardiac-specific angiotensin-converting enzyme (ACE) …

[PDF][PDF] NACHO engages N-glycosylation ER chaperone pathways for α7 nicotinic receptor assembly

HJ Kweon, S Gu, E Witham, M Dhara, H Yu… - Cell reports, 2020 - cell.com
The α7 nicotinic acetylcholine receptor participates in diverse aspects of brain physiology and
disease. Neurons tightly control α7 assembly, which relies upon NACHO, an endoplasmic …

[HTML][HTML] Oxygen-sensing neurons reciprocally regulate peripheral lipid metabolism via neuropeptide signaling in Caenorhabditis elegans

R Hussey, NK Littlejohn, E Witham, E Vanstrum… - PLoS …, 2018 - journals.plos.org
The mechanisms by which the sensory environment influences metabolic homeostasis remains
poorly understood. In this report, we show that oxygen, a potent environmental signal, is …

Msx1 homeodomain protein represses the αGSU and GnRH receptor genes during gonadotrope development

…, JD Meadows, EA Witham… - Molecular …, 2013 - academic.oup.com
… After closure of Rathke's pouch on embryonic day (e)12 in the mouse, 5 endocrine cell types
arise in a specific spatial and temporal pattern giving rise to the anterior pituitary (1, 2). The …