Studies in mammals uncovered important signaling roles of nitric oxide (NO), and contributions
to innate immunity. Suggestions of conservation led us to explore the involvement of NO …

The innate immune system is ancient and highly conserved. It is the first line of defense and
the only recognizable immune system in the vast majority of metazoans. Signaling events …

Drosophila melanogaster is a widely used model for the characterization of blood cell
development and function, with an array of protocols for the manipulation and visualization of fixed …

Pathogen-mediated damage to the intestinal epithelium activates compensatory growth and
differentiation repair programs in progenitor cells. Accelerated progenitor growth …

Many metazoan cells can take up exogenous double-stranded (ds) RNA and use it to initiate
an RNA silencing response, however, the mechanism for this uptake is ill-defined. Here, we …

Phagocytosis is a highly conserved aspect of innate immunity. We used Drosophila melanogaster
S2 cells as a model system to study the phagocytosis of Candida albicans, the major …

Much of our understanding of animal cell cytokinesis centers on the regulation of the equatorial
acto-myosin contractile ring that drives the rapid ingression of a deep cleavage furrow [1–…

We have previously identified the E3 ubiquitin ligase-inducible degrader of the low density
lipoprotein receptor (LDLR) (Idol) as a post-translational modulator of LDLR levels. Idol is a …

While the structure and regulatory networks that govern type-six secretion system (T6SS)
activity of Vibrio cholerae are becoming increasingly clear, we know less about the role of …

To coordinate a meaningful response to infection or tissue damage, Tumor Necrosis Factor (TNF)
triggers a spectrum of reactions in target cells that includes cell activation, …