The recent 2014 Nobel Prize in chemistry honored an era of discoveries and technical
advancements in the field of super‐resolution microscopy. However, the applications of diffraction…

The synapsins, the first identified synaptic vesicle-specific proteins, are phosphorylated on
multiple sites by a number of protein kinases and are involved in neurite outgrowth and …

The orchestration of protein production and degradation, and the regulation of protein lifetimes,
play a central role in the majority of biological processes. Recent advances in proteomics …

To the Editor: Although conventional microscopes have a resolution limited by diffraction to
about half the wavelength of light, several recent advances have led to microscopy methods …

The turnover of brain proteins is critical for organism survival, and its perturbations are linked
to pathology. Nevertheless, protein lifetimes have been difficult to obtain in vivo. They are …

Investigations into brain function and disease depend on the precise classification of neural
cell types. Cells of the oligodendrocyte lineage differ greatly in their morphology, but …

Aging is a prominent risk factor for neurodegenerative disorders (NDDs); however, the
molecular mechanisms rendering the aged brain particularly susceptible to neurodegeneration …

The precise polarization and orientation of developing neurons is essential for the correct
wiring of the brain. In pyramidal excitatory neurons, polarization begins with the sprouting of …

Aged proteins can become hazardous to cellular function, by accumulating molecular damage.
This implies that cells should preferentially rely on newly produced ones. We tested this …

To date, the effects of specific modification types and sites on protein lifetime have not been
systematically illustrated. Here, we describe a proteomic method, DeltaSILAC, to …