Environmental risk assessment and decision-making strategies over the last several
decades have become increasingly more sophisticated, information-intensive, and complex, …

Assessments of human health and ecological risk draw upon multiple types and sources of
information, requiring the integration of multiple lines of evidence before conclusions may be …

Originally rising to notoriety for their role in the regulation of aging, sirtuins are a family of
NAD + -dependent enzymes that have been connected to a steadily growing set of biological …

Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral
disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute …

Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of
neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic variants …

We present the largest exome sequencing study of autism spectrum disorder (ASD) to date (n
= 35,584 total samples, 11,986 with ASD). Using an enhanced analytical framework to …

Rare coding variation has historically provided the most direct connections between gene
function and disease pathogenesis. By meta-analysing the whole exomes of 24,248 …

Some individuals with autism spectrum disorder (ASD) carry functional mutations rarely
observed in the general population. We explored the genes disrupted by these variants from …

Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting
substantial pleiotropy of contributing loci. However, the nature and mechanisms of these …

Naive T cell stimulation activates anabolic metabolism to fuel the transition from quiescence
to growth and proliferation. Here we show that naive CD4 + T cell activation induces a …