Previous efforts to control cellular behaviour have largely relied upon various forms of genetic
engineering. Once the genetic content of a living cell is modified, the behaviour of that cell …

The cell-free transcription–translation of multiple proteins typically exploits genes placed
behind strong transcriptional promoters that reside on separate pieces of DNA so that protein …

Imaging makes a significant contribution to the diagnosis, prognosis and follow-up in sarcoidosis.
Despite its increasing use, the role of computed tomography (CT) scanning in patients …

Although RNA synthesis can be reliably controlled with different T7 transcriptional promoters
during cell-free gene expression with the PURE system, protein synthesis remains largely …

… (D) The fraction of fully assembled complexes f complex , as a function of [c] 0 and [y] 0
for [r] 0 = 500 nM. The heat map shows calculated values of f complex , whereas the circles …

Optogenetic tools have revolutionized the study of receptor-mediated processes, but such
tools are lacking for RNA-controlled systems. In particular, light-activated regulatory RNAs are …

Laboratory evolution of functional RNAs has applications in many areas of chemical and
synthetic biology. In vitro selections critically depend on the presence of functional molecules, …

A mechanism of nucleoside triphosphorylation would have been critical in an evolving “RNA
world” to provide high‐energy substrates for reactions such as RNA polymerization. …

In 2014, an international group of scholars from various fields analysed the “societal dimensions”
of synthetic biology in an interdisciplinary summer school. Here, we report and discuss …

Background/Objective: Skin fibrosis is the result of aberrant processes leading to abnormal
deposition of extracellular matrix (ECM) in the dermis. In healthy skin, keratinocytes …