Motivation Polygenic scores have become a central tool in human genetics research.
LDpred is a popular method for deriving polygenic scores based on summary statistics and a …

Motivation Genome-wide datasets produced for association studies have dramatically
increased in size over the past few years, with modern datasets commonly including millions of …

R package pcadapt is a user-friendly R package for performing genome scans for local
adaptation. Here, we present version 4 of pcadapt which substantially improves computational …

The low portability of polygenic scores (PGSs) across global populations is a major concern
that must be addressed before PGSs can be used for everyone in the clinic. Indeed, …

Polygenic prediction has the potential to contribute to precision medicine. Clumping and
thresholding (C+T) is a widely used method to derive polygenic scores. When using C+T, …

… LDAK-Bolt-Predict considers 6 values for p (0.01, 0.02, 0.05, 0.1, 0.2, and 0.5) and three
values for f 2 (0.1, 0.3, and 0.5), resulting in 18 possible pairs for p and f 2 . First LDAK-Bolt-…

… i and variant j, and f j ^ is the estimated allele frequency of variant j (⁠ 2 f j ^ is the mean …
(ie G i , j − 2 f j ^ = 0 when G i , j is missing) and the f j ^ for each variant are estimated using only …

Polygenic scores (PGSs) have limited portability across different groupings of individuals (for
example, by genetic ancestries and/or social determinants of health), preventing their …

Polygenic risk scores (PRS) combine many single-nucleotide polymorphisms into a score
reflecting the genetic risk of developing a disease. Privé, Aschard, and Blum present an …

Antimicrobial peptides (AMPs) are promising drug candidates to target multi-drug resistant
bacteria. The rumen microbiome presents an underexplored resource for the discovery of …