Sperm RNA code programmes the metabolic health of offspring
Mammalian sperm RNA is increasingly recognized as an additional source of paternal
hereditary information beyond DNA. Environmental inputs, including an unhealthy diet, mental …
hereditary information beyond DNA. Environmental inputs, including an unhealthy diet, mental …
Genome recoding by tRNA modifications
F Tuorto, F Lyko - Open biology, 2016 - royalsocietypublishing.org
RNA modifications are emerging as an additional regulatory layer on top of the primary RNA
sequence. These modifications are particularly enriched in tRNAs where they can regulate …
sequence. These modifications are particularly enriched in tRNAs where they can regulate …
RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage
…, F Tuorto, M Meusburger, M Helm, F Lyko - Genes & …, 2010 - genesdev.cshlp.org
Dnmt2 proteins are the most conserved members of the DNA methyltransferase enzyme family,
but their substrate specificity and biological functions have been a subject of controversy. …
but their substrate specificity and biological functions have been a subject of controversy. …
RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis
F Tuorto, R Liebers, T Musch, M Schaefer… - Nature structural & …, 2012 - nature.com
The function of cytosine-C5 methylation, a widespread modification of tRNAs, has remained
obscure, particularly in mammals. We have now developed a mouse strain defective in …
obscure, particularly in mammals. We have now developed a mouse strain defective in …
Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs
The discovery of RNAs (for example, messenger RNAs, non-coding RNAs) in sperm has
opened the possibility that sperm may function by delivering additional paternal information …
opened the possibility that sperm may function by delivering additional paternal information …
[HTML][HTML] RNA–mediated epigenetic heredity requires the cytosine methyltransferase Dnmt2
…, F Tuorto, H Ghanbarian, F Lyko, F Cuzin… - PLoS …, 2013 - journals.plos.org
RNA–mediated transmission of phenotypes is an important way to explain non-Mendelian
heredity. We have previously shown that small non-coding RNAs can induce hereditary …
heredity. We have previously shown that small non-coding RNAs can induce hereditary …
The tRNA methyltransferase Dnmt2 is required for accurate polypeptide synthesis during haematopoiesis
The Dnmt2 enzyme utilizes the catalytic mechanism of eukaryotic DNA methyltransferases
to methylate several tRNA s at cytosine 38. Dnmt2 mutant mice, flies, and plants were …
to methylate several tRNA s at cytosine 38. Dnmt2 mutant mice, flies, and plants were …
Otx2 regulates the extent, identity and fate of neuronal progenitor domains in the ventral midbrain
… (F) Th immunostaining of the DA area in a frontal section close to (D). The arrows in B indicate
the approximate position of frontal sections. InC, inferior colliculus; SuC,superior colliculus…
the approximate position of frontal sections. InC, inferior colliculus; SuC,superior colliculus…
Epilepsy and brain abnormalities in mice lacking the Otx1 gene
The morphogenesis of the brain and the differentiation of the neural structures are highly
complex processes. A series of temporally and spatially regulated morphogenetic events gives …
complex processes. A series of temporally and spatially regulated morphogenetic events gives …
Otx1 and Otx2 activities are required for the normal development of the mouse inner ear
H Morsli, F Tuorto, D Choo, MP Postiglione… - …, 1999 - journals.biologists.com
The Otx1 and Otx2 genes are two murine orthologues of the Orthodenticle (Otd) gene in
Drosophila. In the developing mouse embryo, both Otx genes are expressed in the rostral head …
Drosophila. In the developing mouse embryo, both Otx genes are expressed in the rostral head …