[HTML][HTML] Signaling by steroid hormones in the 3D nuclear space
Initial studies showed that ligand-activated hormone receptors act by binding to the proximal
promoters of individual target genes. Genome-wide studies have now revealed that …
promoters of individual target genes. Genome-wide studies have now revealed that …
Distinct structural transitions of chromatin topological domains correlate with coordinated hormone-induced gene regulation
The human genome is segmented into topologically associating domains (TADs), but the role
of this conserved organization during transient changes in gene expression is not known. …
of this conserved organization during transient changes in gene expression is not known. …
Transcription factors orchestrate dynamic interplay between genome topology and gene regulation during cell reprogramming
Chromosomal architecture is known to influence gene expression, yet its role in controlling
cell fate remains poorly understood. Reprogramming of somatic cells into pluripotent stem …
cell fate remains poorly understood. Reprogramming of somatic cells into pluripotent stem …
Nitrogen recycling and remobilization are differentially controlled by leaf senescence and development stage in Arabidopsis under low nitrogen nutrition
… Frédérik Le Dily Unité de Nutrition Azotée des Plantes, UR511, INRA, F–78000 Versailles,
France (CD, TL, AC, MA, J.-FM-G., CM-D.); Division of Integrated Life Science, Graduate …
France (CD, TL, AC, MA, J.-FM-G., CM-D.); Division of Integrated Life Science, Graduate …
[HTML][HTML] ATP, Mg2+, nuclear phase separation, and genome accessibility
Misregulation of the processes controlling eukaryotic gene expression can result in disease.
Gene expression is influenced by the surrounding chromatin; hence the nuclear …
Gene expression is influenced by the surrounding chromatin; hence the nuclear …
ADP-ribose–derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling
… S1, E and F), a behavior that was not observed in cells exposed to solvent (EtOH) (… (F)
Crystal structure of NUDIX5 homodimer complex with ADPR and Mg 2+ (PDB: … Francois Le Dily …
Crystal structure of NUDIX5 homodimer complex with ADPR and Mg 2+ (PDB: … Francois Le Dily …
CTCF is dispensable for immune cell transdifferentiation but facilitates an acute inflammatory response
Three-dimensional organization of the genome is important for transcriptional regulation 1 ,
2 , 3 , 4 , 5 , 6 – 7 . In mammals, CTCF and the cohesin complex create submegabase …
2 , 3 , 4 , 5 , 6 – 7 . In mammals, CTCF and the cohesin complex create submegabase …
[PDF][PDF] Nucleosome-driven transcription factor binding and gene regulation
Elucidating the global function of a transcription factor implies the identification of its target
genes and genomic binding sites. The role of chromatin in this context is unclear, but the …
genes and genomic binding sites. The role of chromatin in this context is unclear, but the …
Distinct roles of cohesin-SA1 and cohesin-SA2 in 3D chromosome organization
…, G Gómez-López, F Le Dily… - Nature structural & …, 2018 - nature.com
Two variant cohesin complexes containing SMC1, SMC3, RAD21 and either SA1 (also
known as STAG1) or SA2 (also known as STAG2) are present in all cell types. We report here …
known as STAG1) or SA2 (also known as STAG2) are present in all cell types. We report here …
[PDF][PDF] Three-dimensional genomic structure and cohesin occupancy correlate with transcriptional activity during spermatogenesis
Mammalian gametogenesis involves dramatic and tightly regulated chromatin remodeling,
whose regulatory pathways remain largely unexplored. Here, we generate a comprehensive …
whose regulatory pathways remain largely unexplored. Here, we generate a comprehensive …