Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells
B cell–derived chronic lymphocytic leukemia (B-CLL) represents a common malignancy whose
cell derivation and pathogenesis are unknown. Recent studies have shown that >50% of …
cell derivation and pathogenesis are unknown. Recent studies have shown that >50% of …
Transcriptional analysis of the B cell germinal center reaction
The germinal center (GC) reaction is crucial for T cell-dependent immune responses and is
targeted by B cell lymphomagenesis. Here we analyzed the transcriptional changes that …
targeted by B cell lymphomagenesis. Here we analyzed the transcriptional changes that …
A plausible model for the digital response of p53 to DNA damage
…, W Hu, AJ Levine, GA Stolovitzky - Proceedings of the …, 2005 - National Acad Sciences
Recent observations show that the single-cell response of p53 to ionizing radiation (IR) is “digital”
in that it is the number of oscillations rather than the amplitude of p53 that shows …
in that it is the number of oscillations rather than the amplitude of p53 that shows …
Formation of regulatory patterns during signal propagation in a mammalian cellular network
…, PT Ram, JJ Rice, A Kershenbaum, GA Stolovitzky… - Science, 2005 - science.org
We developed a model of 545 components (nodes) and 1259 interactions representing
signaling pathways and cellular machines in the hippocampal CA1 neuron. Using graph theory …
signaling pathways and cellular machines in the hippocampal CA1 neuron. Using graph theory …
[HTML][HTML] Identification of Hodgkin and Reed-Sternberg cell-specific genes by gene expression profiling
…, G Cattoretti, Y Tu, GA Stolovitzky… - The Journal of …, 2003 - Am Soc Clin Investig
Hodgkin lymphoma (HL) is a malignancy of unknown pathogenesis. The malignant Hodgkin
and Reed/Sternberg (HRS) cells derive from germinal center B cells (or rarely, T cells) but …
and Reed/Sternberg (HRS) cells derive from germinal center B cells (or rarely, T cells) but …
Tracking CD40 signaling during germinal center development
Substantial evidence indicates that signaling through the CD40 receptor (CD40) is required
for germinal center (GC) and memory B-cell formation. However, it is not fully understood at …
for germinal center (GC) and memory B-cell formation. However, it is not fully understood at …
Identification of a global gene expression signature of B-chronic lymphocytic leukemia
DF Jelinek, RC Tschumper, GA Stolovitzky… - Molecular Cancer …, 2003 - AACR
B-chronic lymphocytic leukemia (B-CLL) is an adult-onset leukemia characterized by
significant accumulation of apoptosis-resistant monoclonal B lymphocytes. In this study, we …
significant accumulation of apoptosis-resistant monoclonal B lymphocytes. In this study, we …
[HTML][HTML] Improving breast cancer survival analysis through competition-based multidimensional modeling
Breast cancer is the most common malignancy in women and is responsible for hundreds of
thousands of deaths annually. As with most cancers, it is a heterogeneous disease and …
thousands of deaths annually. As with most cancers, it is a heterogeneous disease and …
p53–Mdm2 loop controlled by a balance of its feedback strength and effective dampening using ATM and delayed feedback
…, L Ma, JJ Rice, W Hu, AJ Levine, GA Stolovitzky - IEE Proceedings-Systems …, 2005 - IET
When the genomic integrity of a cell is challenged, its fate is determined in part by signals
conveyed by the p53 tumour suppressor protein. It was observed recently that such signals are …
conveyed by the p53 tumour suppressor protein. It was observed recently that such signals are …
Gene expression dynamics during germinal center transit in B cells
The germinal center (GC) reaction in T cell dependent antibody responses is crucial for the
generation of B cell memory and plays a critical role in B cell lymphomagenesis. To gain …
generation of B cell memory and plays a critical role in B cell lymphomagenesis. To gain …