As global aquaculture fish production continues to expand, an improved understanding of
how environmental factors interact in fish health and production is needed. Significant …

Background Previously, we have shown that bacterial cold water disease (BCWD) resistance
in rainbow trout can be improved using traditional family-based selection, but progress has …

Antiviral immunity in fish is not well understood. In mammals, Toll-like receptor (TLR) 3 is
involved in double-stranded RNA recognition and host immune response activation. Here, we …

… DNA from this clone has also been subjected to genome sequencing (GD Wiens et al.,
unpublished data) and is part of a model system for studying host—pathogen–environmental …

The tumor necrosis factor superfamily (TNFSF) and the TNF receptor superfamily (TNFRSF)
have an ancient evolutionary origin that can be traced back to single copy genes within …

A family-based selection program was initiated at the National Center for Cool and Cold
Water Aquaculture in 2005 to improve resistance to bacterial cold water disease (BCWD) in …

The objectives of this study were to estimate the heritabilities for and genetic correlations
among resistance to bacterial cold-water disease and growth traits in a population of rainbow …

Commensal microorganisms present at mucosal surfaces play a vital role in protecting the
host organism from bacterial infection. There are multiple factors that contribute to selecting …

Induction of the innate immune pathways is critical for early anti-viral defense but there is
limited understanding of how teleost fish recognize viral molecules and activate these pathways…

… Further evidence supporting the identification of 4-1BBL orthologs is that we have isolated
a rainbow trout gene with similarities to the 4-1BB receptor (GD Wiens, unpublished data). …