A new scientific frontier opened in 2009 with the start of operations of the world’s first x-ray
free-electron laser (FEL), the Linac Coherent Light Source (LCLS), at SLAC National …

Plastic pollution and climate change have commonly been treated as two separate issues
and sometimes are even seen as competing. Here we present an alternative view that these …

… Jin provides a view from computational intelligence and meta-heuristic global optimization,
and Williams draws upon a machine learning and data mining background applied as a …

X-ray crystallography provides the vast majority of macromolecular structures, but the success
of the method relies on growing crystals of sufficient size. In conventional measurements, …

Climate strongly influences global wildfire activity, and recent wildfire surges may signal fire
weather-induced pyrogeographic shifts. Here we use three daily global climate data sets …

Structure determination of proteins and other macromolecules has historically required the
growth of high-quality crystals sufficiently large to diffract x-rays efficiently while withstanding …

G-protein-coupled receptors (GPCRs) signal primarily through G proteins or arrestins. Arrestin
binding to GPCRs blocks G protein interaction and redirects signalling to numerous G-…

Coherent X-ray diffraction imaging is a rapidly advancing form of microscopy: diffraction
patterns, measured using the latest third-generation synchrotron radiation sources, can be …

Background Antibiotics are widely administered to children with the intention of preventing
urinary tract infection, but adequately powered, placebo-controlled trials regarding efficacy …

Lipidic cubic phase (LCP) crystallization has proven successful for high-resolution structure
determination of challenging membrane proteins. Here we present a technique for extruding …