… Here, Stuart Schreiber and Gerald Crabtree review recent findings that indicate CsA and
FK506 operate as prodrugs: they bind endogenous intracellular receptors, the immunophilins, …

THE immunosuppressive drugs cyclosporin A (CsA) and FKS06 both interfere with a Ca 2+ -sensitive
T-cell signal transduction pathway 1–4 thereby preventing the activation of specific …

Calcium signaling activates the phosphatase calcineurin and induces movement of NFATc
proteins into the nucleus, where they cooperate with other proteins to form complexes on DNA…

The macrolide rapamycin blocks cell cycle progression in yeast and various animal cells by
an unknown mechanism. We demonstrate that rapamycln blocks the phosphorylatlon and …

Subunits of mammalian SWI/SNF (mSWI/SNF or BAF) complexes have recently been
implicated as tumor suppressors in human malignancies. To understand the full extent of their …

CYCLOSPORINA and FK506 inhibit T- and B-cell activation and other processes essential to
an effective immune response 1–3 . In T lymphocytes these drugs disrupt an unknown step …

New methods for the genome-wide analysis of chromatin are providing insight into its roles
in development and their underlying mechanisms. Current studies indicate that chromatin is …

A surprising and yet vexing outcome of the rapid progress made in understanding signal
transduction is the observation that while activation of specific receptors leads to highly specific …

Molecules involved in the antigen receptor-dependent regulation of early T cell activation
genes were investigated with the use of functional sequences of the T cell activation-specific …

Dimerization and oligomerization are general biological control mechanisms contributing to
the activation of cell membrane receptors, transcription factors, vesicle fusion proteins, and …