Myelin-specific T lymphocytes are considered essential in the pathogenesis of multiple
sclerosis. The myelin basic protein peptide (aa 83–99) represents one candidate antigen; …

The proteins encoded by the SIR1, SIR2, SIR3 and SIR4 genes in yeast repress
transcription at the mating type loci and telomeres. Among the SIR genes, SIR2 is the most …

… After addition of 0.065 g lysozyme in 6.25 ml 2 mM EDTA and incubation on ice for 10 min, …
Four rats were injected each with 200-250 #g of fusion peptide and boosted with 100 ttg. The …

Gene therapy by expression constructs or down-regulation of certain genes has shown great
potential for the treatment of various diseases. The wide clinical application of nucleic acid …

Malignant gliomas are almost uniformly fatal and display exquisite radiation resistance.
Glioma cells lacking wild-type (WT) p53 function are more susceptible to radiation-induced …

The development of novel methods plays a fundamental role in early diagnosis and controlling
of neurological disorders (NDs). Blood-brain barrier (BBB) is the most challenging barrier …

Curcumin is a naturally occurring nutraceutical compound with a number of therapeutic and
biological activities such as antioxidant, anti‐inflammatory, anti‐diabetic, antitumor, and …

T cell responses targeting myelin antigens are possibly involved in the pathogenesis of
demyelinating diseases, such as multiple sclerosis (MS). Little is known about human T cell …

… These attributes are correlated with the texture of the rock through a carefully constructed
grayscale filter function G(x) (Figure 5). For this model implementation, the filter function G(x) is …

The blood–brain barrier (BBB) acts as a barrier to prevent the central nervous system (CNS)
from damage by substances that originate from the blood circulation. The BBB limits drug …