… where x is the n-dimensional state vector (often corresponding to concentrations), inline
image is the time-derivative of this vector, x(t) is the state at time t, and f and g are vectors of …

Type 2 diabetes originates in an expanding adipose tissue that for unknown reasons
becomes insulin resistant. Insulin resistance reflects impairments in insulin signaling, but …

Signaling pathways that only a few years ago appeared simple and understandable, albeit
far from complete, have evolved into very complex multi-layered networks of cellular control …

… Plasma membrane and mitochondria were removed by centrifugation of the 1000 × g
supernatant at 16,000 × g for 20 min. The supernatant was centrifuged at 210,000 × g for 75 min to …

Type 2 diabetes is a metabolic disease that profoundly affects energy homeostasis. The
disease involves failure at several levels and subsystems and is characterized by insulin …

… of the states at time t = 0, where these values are described by the parameters x 0 , inline
image are the simulated model outputs corresponding to the measured experimental signals, g …

… less than 45%; (6) serum ceruloplasmin level greater than 0.20 g/L; (7) serum α 1 -antitrypsin
level greater than 0.86 g/L for men and greater than 0.94 g/L for women; and (8) alanine …

Functional magnetic resonance imaging (fMRI) of hemodynamic changes captured in the
blood oxygen level-dependent (BOLD) response contains information of brain activity. The …

… The additional frequency change caused by amplitude changes is determined by Im(g)/Re(g).
The bifurcation parameter μ is ([Glc x ] 0 −[Glc x ] 0 , bif )/[Glc x ] 0 , bif in the 20D and the …

… G ∂ G where G is the plasma concentration of glucose. Further, the varied model component
in the insulin sensitivity index is the insulin concentration, which we denote I . If everything …