Background Multiple sclerosis (MS) is a leading cause of disability in young adults.
Susceptibility to MS is determined by environmental exposure on the background of genetic risk …

Understanding the pathogenesis of complex immunologic disorders such as multiple
sclerosis (MS) is challenging. Abnormalities in many different cell types are observed in the …

Background: Epstein-Barr virus (EBV) infection is widely considered to be a risk factor for
multiple sclerosis (MS). A previous meta-analysis estimated an odds ratio (OR) for MS in …

… The procedure accounts for compositional biases by requiring that the randomized location
of a segment remains on the same chromosome and preserves the local G+C content. From …

Objective Neurofilament light chains (NfL) are unique to neuronal cells, are shed to the
cerebrospinal fluid (CSF), and are detectable at low concentrations in peripheral blood. Various …

Background and objective: We explored which clinical and biochemical variables predict
conversion from clinically isolated syndrome (CIS) to clinically definite multiple sclerosis (CDMS…

Background Multiple sclerosis (MS) appears to develop in genetically susceptible individuals
as a result of environmental exposures. Epstein-Barr virus (EBV) infection is an almost …

Background HLA-DRB1*15 genotype, previous infection with Epstein-Barr virus, and
vitamin D insufficiency are susceptibility factors for multiple sclerosis, but whether they act …

Neuro-axonal injury is a key factor in the development of permanent disability in multiple
sclerosis. Neurofilament light chain in peripheral blood has recently emerged as a biofluid …

Objective: Multiple sclerosis (MS) is a complex neurological disease. Genetic linkage analysis
and genotyping of candidate genes in families with 4 or more affected individuals more …