Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants
…, J Rosand, R Clarke, S Gretarsdottir, G Thorleifsson… - Stroke, 2014 - Am Heart Assoc
Background and Purpose— Ischemic stroke (IS) and coronary artery disease (CAD) share
several risk factors and each has a substantial heritability. We conducted a genome-wide …
several risk factors and each has a substantial heritability. We conducted a genome-wide …
A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip
…, YFM Ramos, G Thorleifsson… - Annals of the …, 2014 - ard.bmj.com
Objectives Osteoarthritis (OA) is the most common form of arthritis with a clear genetic component.
To identify novel loci associated with hip OA we performed a meta-analysis of genome…
To identify novel loci associated with hip OA we performed a meta-analysis of genome…
Biological, clinical and population relevance of 95 loci for blood lipids
…, SL Ricketts, JC Bis, YS Aulchenko, G Thorleifsson… - Nature, 2010 - nature.com
Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density
lipoprotein cholesterol and triglycerides are among the most important risk factors for …
lipoprotein cholesterol and triglycerides are among the most important risk factors for …
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes
SFA Grant, G Thorleifsson, I Reynisdottir… - Nature …, 2006 - nature.com
We have previously reported suggestive linkage of type 2 diabetes mellitus to chromosome
10q 1 . We genotyped 228 microsatellite markers in Icelandic individuals with type 2 …
10q 1 . We genotyped 228 microsatellite markers in Icelandic individuals with type 2 …
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic
traits, we performed meta-analyses of 21 genome-wide association studies informative for …
traits, we performed meta-analyses of 21 genome-wide association studies informative for …
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
…, CJ Willer, SI Berndt, KL Monda, G Thorleifsson… - Nature …, 2010 - nature.com
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …
Rate of de novo mutations and the importance of father's age to disease risk
…, GB Walters, S Steinberg, H Helgason, G Thorleifsson… - Nature, 2012 - nature.com
Mutations generate sequence diversity and provide a substrate for selection. The rate of de
novo mutations is therefore of major importance to evolution. Here we conduct a study of …
novo mutations is therefore of major importance to evolution. Here we conduct a study of …
[HTML][HTML] Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study
…, JC Hopewell, JF Thompson, M Li, G Thorleifsson… - The Lancet, 2012 - thelancet.com
Background High plasma HDL cholesterol is associated with reduced risk of myocardial
infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are …
infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are …
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
…, S Tennstedt, G Thorgeirsson, G Thorleifsson… - Nature …, 2011 - nature.com
We performed a meta-analysis of 14 genome-wide association studies of coronary artery
disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of …
disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of …
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D)
and 38,987 controls of European descent and following up previously unidentified meta-…
and 38,987 controls of European descent and following up previously unidentified meta-…