User profiles for H. E. Arda
 | H. Efsun ArdaStadtman Investigator, National Institutes of Health Verified email at nih.gov Cited by 2079 |
[PDF][PDF] Gene regulatory networks governing pancreas development
HE Arda, CM Benitez, SK Kim - Developmental cell, 2013 - cell.com
Elucidation of cellular and gene regulatory networks (GRNs) governing organ development
will accelerate progress toward tissue replacement. Here, we have compiled reference …
will accelerate progress toward tissue replacement. Here, we have compiled reference …
[PDF][PDF] Single-cell analysis of human pancreas reveals transcriptional signatures of aging and somatic mutation patterns
As organisms age, cells accumulate genetic and epigenetic errors that eventually lead to
impaired organ function or catastrophic transformation such as cancer. Because aging reflects …
impaired organ function or catastrophic transformation such as cancer. Because aging reflects …
[HTML][HTML] Diet-induced developmental acceleration independent of TOR and insulin in C. elegans
Dietary composition has major effects on physiology. Here, we show that developmental rate,
reproduction, and lifespan are altered in C. elegans fed Comamonas DA1877 relative to …
reproduction, and lifespan are altered in C. elegans fed Comamonas DA1877 relative to …
[PDF][PDF] Age-dependent pancreatic gene regulation reveals mechanisms governing human β cell function
… He is a member of the scientific advisory board (SAB) of Axiomx, Genapsys, and SensOmics.
HYC is a founder of Epinomics and served on the SAB of RaNA Therapeutics. Joint work in …
HYC is a founder of Epinomics and served on the SAB of RaNA Therapeutics. Joint work in …
Gene-centered regulatory networks
HE Arda, AJM Walhout - Briefings in functional genomics, 2010 - academic.oup.com
… Efsun Arda is a Graduate Student in the Interdisciplinary Graduate Program and Program
in … process-specific GRNs can also be characterized by Y1H assays (Arda et al., submitted). …
in … process-specific GRNs can also be characterized by Y1H assays (Arda et al., submitted). …
[HTML][HTML] Integration of metabolic and gene regulatory networks modulates the C. elegans dietary response
Expression profiles are tailored according to dietary input. However, the networks that control
dietary responses remain largely uncharacterized. Here, we combine forward and reverse …
dietary responses remain largely uncharacterized. Here, we combine forward and reverse …
Aggressive PDACs show hypomethylation of repetitive elements and the execution of an intrinsic IFN program linked to a ductal cell of origin
The mutational landscapes of PDAC alone cannot explain the observed interpatient
heterogeneity. We identified two PDAC subtypes characterized by differential DNA methylation, …
heterogeneity. We identified two PDAC subtypes characterized by differential DNA methylation, …
Functional modularity of nuclear hormone receptors in a Caenorhabditis elegans metabolic gene regulatory network
Gene regulatory networks (GRNs) provide insights into the mechanisms of differential gene
expression at a systems level. GRNs that relate to metazoan development have been …
expression at a systems level. GRNs that relate to metazoan development have been …
Single-cell transcriptome and accessible chromatin dynamics during endocrine pancreas development
…, NC Sheffield, SK Kim, HE Arda - Proceedings of the …, 2022 - National Acad Sciences
… Batista and the members of the Arda and Kim laboratories for discussions and suggestions.
This work was supported by the Intramural Research Program of the NIH, National Cancer …
This work was supported by the Intramural Research Program of the NIH, National Cancer …
[HTML][HTML] Transcription factor activity mapping of a tissue-specific in vivo gene regulatory network
A wealth of physical interaction data between transcription factors (TFs) and DNA has been
generated, but these interactions often do not have apparent regulatory consequences. …
generated, but these interactions often do not have apparent regulatory consequences. …