The pH of solid tumors is acidic due to increased fermentative metabolism and poor perfusion.
It has been hypothesized that acid pH promotes local invasive growth and metastasis. …

Background The concept of mitochondrial dysfunction in ageing muscle is highly controversial.
In addition, emerging evidence suggests that reduced muscle oxidative capacity and …

Purpose : Hypoxia and acidosis develop in in situ tumors as cellular expansion increases the
diffusion distance of substrates and metabolites from blood vessels deep to the basement …

The tumor microenvironment is acidic as a consequence of upregulated glycolysis and poor
perfusion and this acidity, in turn, promotes invasion and metastasis. We have recently …

Background Aging-related disease risk is exacerbated by obesity and physical inactivity. It
is unclear how weight loss and increased activity improve risk in older adults. We aimed to …

OBJECTIVE Some individuals with type 2 diabetes do not reap metabolic benefits from
exercise training, yet the underlying mechanisms of training response variation are largely …

Objective Nicotinamide phosphoribosyl transferase (NAMPT) is the rate-limiting enzyme in
the salvage pathway that produces nicotinamide adenine dinucleotide (NAD + ), an essential …

Background Malignant tumor cells typically metabolize glucose anaerobically to lactic acid
even under normal oxygen tension, a phenomenon called aerobic glycolysis or the Warburg …

The loss of skeletal muscle mass and function with age (sarcopenia) is a critical healthcare
challenge for older adults. 31‐phosphorus magnetic resonance spectroscopy ( 31 P‐MRS) is …

Context: The effects of caloric restriction (CR) on in vivo muscle mitochondrial function in
humans are controversial. Objective: We evaluated muscle mitochondrial function and …