Background The tissue-specific translation elongation factor eEF1A2 was recently shown to
be a potential oncogene that is overexpressed in ovarian cancer. Although there is no direct …

Genetic alterations impacting ubiquitously expressed proteins involved in RNA metabolism
often result in neurodegenerative conditions, with increasing evidence suggesting that …

Translation elongation factor eEF1A, formerly known as EF-1α, exists as two variant forms;
eEF1A1, which is almost ubiquitously expressed, and eEF1A2, whose expression is restricted …

Background Despite sharing 92% sequence identity, paralogous human translation elongation
factor 1 alpha-1 (eEF1A1) and elongation factor 1 alpha-2 (eEF1A2) have different but …

Background The canonical function of EEF1A2, normally expressed only in muscle, brain,
and heart, is in translational elongation, but recent studies suggest a non-canonical function …

The tissue-specific translation elongation factor eEF1A2 is a potential oncogene that is
overexpressed in human ovarian cancer. eEF1A2 is highly similar (98%) to the near-ubiquitously …

Wasted (wst) is a spontaneous autosomal recessive mutation in which the gene encoding
translation factor eEF1A2 is deleted. Homozygous mice show tremors and disturbances of gait …

Translation elongation factor eEF1A (eukaryotic elongation factor 1A) exists as two individually
encoded variants in mammals, which are 98% similar and 92% identical at the amino …

Translation elongation factor 1A2 ( eEF 1A2), uniquely among translation factors, is expressed
specifically in neurons and muscle. e EF 1 A 2‐null mutant wasted mice develop an …

Translation elongation factor isoform eEF1A2 is expressed in muscle and neurons. Deletion
of eEF1A2 in mice gives rise to the neurodegenerative phenotype “wasted” (wst). Mice …