User profiles for H. M. Marriott
Helen M MarriottLecturer in Respiratory Infection, University of Sheffield Verified email at sheffield.ac.uk Cited by 5195 |
Pneumolysin: a double-edged sword during the host-pathogen interaction
HM Marriott, TJ Mitchell… - Current molecular …, 2008 - ingentaconnect.com
The cholesterol-dependent cytolysins are pore-forming toxins. Pneumolysin is the cytolysin
produced by Streptococcus pneumoniae and is a key virulence factor. The protein contains …
produced by Streptococcus pneumoniae and is a key virulence factor. The protein contains …
Alveolar macrophages in pulmonary host defence–the unrecognized role of apoptosis as a mechanism of intracellular bacterial killing
…, J Cole, MA Bewley, HM Marriott… - Clinical & …, 2013 - academic.oup.com
Alveolar macrophages play an essential role in clearing bacteria from the lower airway, as
the resident phagocyte alveolar macrophages must both phagocytose and kill bacteria, and if …
the resident phagocyte alveolar macrophages must both phagocytose and kill bacteria, and if …
[HTML][HTML] The identification of markers of macrophage differentiation in PMA-stimulated THP-1 cells and monocyte-derived macrophages
Differentiated macrophages are the resident tissue phagocytes and sentinel cells of the
innate immune response. The phenotype of mature tissue macrophages represents the …
innate immune response. The phenotype of mature tissue macrophages represents the …
The role of the macrophage in lung disease mediated by bacteria
HM Marriott, DH Dockrell - Experimental lung research, 2007 - Taylor & Francis
… Macrophage apoptosis and alterations in Mcl-1 can be observed for a variety of other
pathogens, including Haemophilus influenzae and Escherichia coli (Marriott and Dockrell …
pathogens, including Haemophilus influenzae and Escherichia coli (Marriott and Dockrell …
Alveolar macrophage apoptosis contributes to pneumococcal clearance in a resolving model of pulmonary infection
The role of alveolar macrophages (AM) in host defense against pulmonary infection has
been difficult to establish using in vivo models. This may reflect a reliance on models of …
been difficult to establish using in vivo models. This may reflect a reliance on models of …
[HTML][HTML] Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice
…, K Vaughan, HM Marriott… - The Journal of …, 2011 - Am Soc Clin Investig
The regulation of neutrophil lifespan by induction of apoptosis is critical for maintaining an
effective host response and preventing excessive inflammation. The hypoxia-inducible factor (…
effective host response and preventing excessive inflammation. The hypoxia-inducible factor (…
TNF-related apoptosis-inducing ligand (TRAIL) regulates inflammatory neutrophil apoptosis and enhances resolution of inflammation
EE McGrath, HM Marriott, A Lawrie… - Journal of leukocyte …, 2011 - academic.oup.com
Novel therapeutics targeting neutrophilic inflammation are a major unmet clinical need in
acute and chronic inflammation. The timely induction of neutrophil apoptosis is critical for …
acute and chronic inflammation. The timely induction of neutrophil apoptosis is critical for …
Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish
Neutrophil lifespan and function are regulated by hypoxia via components of the hypoxia
inducible factor (HIF)/von Hippel Lindau/hydroxylase pathway, including specific roles for HIF-…
inducible factor (HIF)/von Hippel Lindau/hydroxylase pathway, including specific roles for HIF-…
Inhibition of neutrophil apoptosis by ATP is mediated by the P2Y11 receptor
Neutrophils undergo rapid constitutive apoptosis that is delayed by a range of pathogen-and
host-derived inflammatory mediators. We have investigated the ability of the nucleotide ATP…
host-derived inflammatory mediators. We have investigated the ability of the nucleotide ATP…
Nitric oxide levels regulate macrophage commitment to apoptosis or necrosis during pneumococcal infection
Macrophages are resistant to constitutive apoptosis, but infectious stimuli can induce either
microbial or host‐mediated macrophage apoptosis. Phagocytosis and killing of opsonized …
microbial or host‐mediated macrophage apoptosis. Phagocytosis and killing of opsonized …