Fluorouracil (5FU) is still considered the most active antineoplastic agent in the treatment of
advanced colorectal cancer. The drug needs to be converted to the nucleotide level in order …

The antineoplastic drug doxorubicin is capable of generating a variety of free radical species
in subcellular systems and this capacity has been considered critical for its antitumor action…

Contrary to initial expectations, angiogenesis inhibitors can cause toxicities in patients with
cancer. The toxicity profiles of these inhibitors reflect the disturbance of growth factor …

Background: Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that regulates gene
expression in critical pathways involved in tumor growth and metastases. In this report, we …

… HM Energy metabolism in multidrug resistant tumor cells: a review. J. Cell. … A-, and Pinedo.
HM Analysis of human asciteseffect tin clonogenic growth of human tumor cell lines and NRK-…

The multidrug-resistance associated protein MRP is a 180- to 195-kDa membrane protein
associated with resistance of human tumor cells to cytotoxic drugs. We have investigated how …

Multidrug-resistant cancer cells frequently overexpress the 110-kD LRP protein (originally
named Lung Resistance-related Protein). LRP overexpression has been found to predict a …

Purpose: α-galactosylceramide (KRN7000) is a glycosphingolipid that has been shown to
inhibit tumor growth and to prolong survival in inoculated mice through activation of natural …

BACKGROUND Hypoxia‐inducible factor‐1 (HIF‐1) is a transcription factor that plays an
important role in tumor growth and metastasis by regulating energy metabolism and inducing …

… van Ark-Otte and HM Pinedo are at the Department of Oncology, Free University Hospital,
PO Box 7057, 1007 MB Amsterdam, The Netherlands; B. Winograd was at the EORTC New …