A compelling long-term goal of cancer biology is to understand the crucial players during
tumorigenesis in order to develop new interventions. Here, we review how the four non-…

&HE elementary excitations in helium II have been the object of extensive study in the past
twenty years. The phonon-roton type dispersion curve'was first introduced to account for …

Reproductive history is the strongest risk factor for breast cancer after age, genetics and
breast density 1 , 2 . Increased breast cancer risk is entwined with a greater number of ovarian …

Single-cell analyses have revealed extensive heterogeneity between and within human
tumours 1 , 2 , 3 – 4 , but complex single-cell phenotypes and their spatial context are not at …

Single-cell, spatially resolved omics analysis of tissues is poised to transform biomedical
research and clinical practice. We have developed an open-source, computational histology …

To build comprehensive models of cellular states and interactions in normal and diseased
tissue, genetic and proteomic information must be extracted with single-cell and spatial …

Genomic alterations shape cell phenotypes and the structure of tumor ecosystems in poorly
defined ways. To investigate these relationships, we used imaging mass cytometry to …

Cancer-associated fibroblasts (CAFs) drive tumour progression, but the emergence of this
cell state is poorly understood. A broad spectrum of metalloproteinases, controlled by the …

Systemic and local signals must be integrated by mammary stem and progenitor cells to
regulate their cyclic growth and turnover in the adult gland. Here, we show RANK-positive …

Although breast cancer mortality is largely caused by metastasis, clinical decisions are based
on analysis of the primary tumor and on lymph node involvement but not on the phenotype …