User profiles for H. Hegyi
Hedi Hegyigroup leader at CEITEC - Central European Institute of Technology Verified email at ceitec.muni.cz Cited by 3219 |
[HTML][HTML] The relationship between protein structure and function: a comprehensive survey with application to the yeast genome
H Hegyi, M Gerstein - Journal of molecular biology, 1999 - Elsevier
For most proteins in the genome databases, function is predicted via sequence comparison.
In spite of the popularity of this approach, the extent to which it can be reliably applied is …
In spite of the popularity of this approach, the extent to which it can be reliably applied is …
[HTML][HTML] Panmicrobial oligonucleotide array for diagnosis of infectious diseases
… at 80C, and added to GreeneChip for hybridization for 16 h at 65C. After 10-min washes at
room … were added and incubated at 65C for 1 h. Slides were washed as before, air dried, and …
room … were added and incubated at 65C for 1 h. Slides were washed as before, air dried, and …
The implications of alternative splicing in the ENCODE protein complement
…, P Ólason, M Albrecht, H Hegyi… - Proceedings of the …, 2007 - National Acad Sciences
Alternative premessenger RNA splicing enables genes to generate more than one gene
product. Splicing events that occur within protein coding regions have the potential to alter the …
product. Splicing events that occur within protein coding regions have the potential to alter the …
[HTML][HTML] The relationship between proteome size, structural disorder and organism complexity
Background Sequencing the genomes of the first few eukaryotes created the impression
that gene number shows no correlation with organism complexity, often referred to as the G-…
that gene number shows no correlation with organism complexity, often referred to as the G-…
The protein phosphatase 2C (PP2C) superfamily: detection of bacterial homologues
A thorough sequence analysis of the various members of the eukaryotic protein serine/threonine
phosphatase 2C (PP2C) family revealed the conservation of 11 motifs. These motifs …
phosphatase 2C (PP2C) family revealed the conservation of 11 motifs. These motifs …
Molecular fossils in the human genome: identification and analysis of the pseudogenes in chromosomes 21 and 22
We have developed an initial approach for annotating and surveying pseudogenes in the
human genome. We search human genomic DNA for regions that are similar to known protein …
human genome. We search human genomic DNA for regions that are similar to known protein …
Comparing genomes in terms of protein structure: surveys of a finite parts list
M Gerstein, H Hegyi - FEMS Microbiology Reviews, 1998 - academic.oup.com
… coli and H. influenzae revealed 116 genes that are present only in the latter [37]. Differential
… coli are missing in H. influenzae, and the metabolism in the latter seems to be biased to a …
… coli are missing in H. influenzae, and the metabolism in the latter seems to be biased to a …
Annotation transfer for genomics: measuring functional divergence in multi-domain proteins
H Hegyi, M Gerstein - Genome research, 2001 - genome.cshlp.org
Annotation transfer is a principal process in genome annotation. It involves “transferring”
structural and functional annotation to uncharacterized open reading frames (ORFs) in a newly …
structural and functional annotation to uncharacterized open reading frames (ORFs) in a newly …
[HTML][HTML] Intrinsic structural disorder confers cellular viability on oncogenic fusion proteins
Chromosomal translocations, which often generate chimeric proteins by fusing segments of
two distinct genes, represent the single major genetic aberration leading to cancer. We …
two distinct genes, represent the single major genetic aberration leading to cancer. We …
[HTML][HTML] Structural disorder promotes assembly of protein complexes
Background The idea that the assembly of protein complexes is linked with protein disorder
has been inferred from a few large complexes, such as the viral capsid or bacterial flagellar …
has been inferred from a few large complexes, such as the viral capsid or bacterial flagellar …