Development of envelope protein antigens to serologically differentiate Zika virus infection from dengue virus infection
…, HL Dos Reis, T Singh, H Heimsath… - Journal of clinical …, 2018 - Am Soc Microbiol
… Infected cell foci were detected 48 h after infection, following fixation with 4% … monoclonal
antibody E60 (27) for 2 h at room temperature. After incubation for 1 h with a 1:5,000 dilution of …
antibody E60 (27) for 2 h at room temperature. After incubation for 1 h with a 1:5,000 dilution of …
[HTML][HTML] Intraamniotic Zika virus inoculation of pregnant rhesus macaques produces fetal neurologic disease
…, K Jackson, A Ardeshir, H Heimsath… - Nature …, 2018 - nature.com
Zika virus (ZIKV) infection of pregnant women can cause fetal microcephaly and other
neurologic defects. We describe the development of a non-human primate model to better …
neurologic defects. We describe the development of a non-human primate model to better …
[HTML][HTML] Primary infection with dengue or Zika virus does not affect the severity of heterologous secondary infection in macaques
…, MR Semler, AM Weiler, GL Barry, H Heimsath… - PLoS …, 2019 - journals.plos.org
Zika virus (ZIKV) and dengue virus (DENV) are genetically and antigenically related flaviviruses
that now co-circulate in much of the tropical and subtropical world. The rapid emergence …
that now co-circulate in much of the tropical and subtropical world. The rapid emergence …
Maternal broadly neutralizing antibodies can select for neutralization-resistant, infant-transmitted/founder HIV variants
…, J Chen, M Mengual, AO Douglas, H Heimsath… - MBio, 2020 - Am Soc Microbiol
… To examine the V H mutation differences among the Env-… We detected no significant difference
in the V H somatic … test of no statistical difference in V H somatic-mutation rates between …
in the V H somatic … test of no statistical difference in V H somatic-mutation rates between …
DNA vaccination before conception protects Zika virus–exposed pregnant macaques against prolonged viremia and improves fetal outcomes
…, H Webster, M Dennis, T Singh, H Heimsath… - Science translational …, 2019 - science.org
Zika virus (ZIKV) infection of pregnant women is associated with congenital Zika syndrome (CZS)
and no vaccine is available, although several are being tested in clinical trials. We …
and no vaccine is available, although several are being tested in clinical trials. We …
[HTML][HTML] Efficient transplacental IgG transfer in women infected with Zika virus during pregnancy
…, ML Dennis, HL Itell, HJ Heimsath… - PLoS Neglected …, 2019 - journals.plos.org
… Plates were incubated for 20 minutes, upon which 1N H 2 SO 4 was added to stop the
reaction. A positive result required that the absorbance for a particular plasma was greater than 3-…
reaction. A positive result required that the absorbance for a particular plasma was greater than 3-…
Prior dengue virus serotype 3 infection modulates subsequent plasmablast responses to Zika virus infection in rhesus macaques
…, IG Miller, S Venkatayogi, H Webster, HJ Heimsath… - Mbio, 2024 - Am Soc Microbiol
Immunodominant and highly conserved flavivirus envelope proteins can trigger cross-reactive
IgG antibodies against related flaviviruses, which shapes subsequent protection or …
IgG antibodies against related flaviviruses, which shapes subsequent protection or …
[HTML][HTML] Sutterella and its metabolic pathways positively correlate with vaccine-elicited antibody responses in infant rhesus macaques
D Jiang, R Goswami, M Dennis, H Heimsath… - Frontiers in …, 2023 - frontiersin.org
Introduction It is becoming clearer that the microbiota helps drive responses to vaccines;
however, little is known about the underlying mechanism. In this study, we aimed to identify …
however, little is known about the underlying mechanism. In this study, we aimed to identify …
[HTML][HTML] Polyclonal HIV envelope-specific breast milk antibodies limit founder SHIV acquisition and cell-associated virus loads in infant rhesus monkeys
…, A Kumar, TL Jeffries Jr, JA Eudailey, H Heimsath… - Mucosal …, 2018 - Elsevier
… 2f–h). All animals demonstrated detectable mAb levels in saliva at 1 h post-infusion, the
time of the first SHIV challenge. Saliva mAb levels peaked around 1 day post-infusion in all …
time of the first SHIV challenge. Saliva mAb levels peaked around 1 day post-infusion in all …
Plasmablast response to primary rhesus cytomegalovirus (CMV) infection in a monkey model of congenital CMV transmission
…, DJ Marshall, J Eudailey, H Heimsath… - Clinical and Vaccine …, 2017 - Am Soc Microbiol
… The immunoglobulin (Ig) V H D H J H and V L J L genes of the sorted … V H and V L gene
PCR methods were completed as described previously (41). Briefly, PCR products of Ig V H and …
PCR methods were completed as described previously (41). Briefly, PCR products of Ig V H and …