Given its non-invasive nature, there is increasing interest in the use of transcutaneous
vagus nerve stimulation (tVNS) across basic, translational and clinical research. …

Early‐onset Parkinson's disease (PD) has been associated with different mutations in the
Parkin gene (PARK2). To study distribution and type of Parkin mutations, we carried out a …

Pathological alterations to the locus coeruleus, the major source of noradrenaline in the
brain, are histologically evident in early stages of neurodegenerative diseases. Novel MRI …

… Jacobs thought that Louisa could interest Stowe in Jacobs's … , Jacobs likened her ordeal to
the biblical models of Jacob … for my liberty as faithfully as Jacob served for Rachel. At the end, …

Ablation of metal targets by Ti:sapphire laser radiation is studied. The ablation depth per
pulse is measured for laser pulse durations between 150 fs and 30 ps and fluences ranging …

Point mutations and deletions of mitochondrial DNA (mtDNA) accumulate in a variety of
tissues during ageing in humans 1 , monkeys 2 and rodents 3 . These mutations are unevenly …

MYC contributes to the pathogenesis of a majority of human cancers, yet strategies to
modulate the function of the c-Myc oncoprotein do not exist. Toward this objective, we have …

… questions such as "What is knowledge?", "What do we know?", and "How can we present
knowledge in the schools?" can and should be at the heart of our efforts (Jacobs and Borland …

Aims. This paper describes the Heterodyne Instrument for the Far-Infrared (HIFI) that was
launched onboard ESA's Herschel Space Observatory in May 2009. Methods. The instrument …

Activated macrophages undergo metabolic reprogramming, which drives their pro-inflammatory
phenotype, but the mechanistic basis for this remains obscure. Here, we demonstrate …