Abstract Development of a malaria vaccine remains a critical priority to decrease clinical
disease and mortality and facilitate eradication. Accordingly, RTS,S, a protein-subunit vaccine, …

Immunization with high doses of irradiated sporozoites delivered by the bites of infected
mosquitoes has been shown to induce protective responses against malaria, mediated in part …

CD11c + T-bet + atypical B cells (ABCs) have been identified in the context of vaccination,
acute and chronic infections and autoimmune disease. However, the origins and functions of …

In recent years, various intervention strategies have reduced malaria morbidity and mortality,
but further improvements probably depend upon development of a broadly protective …

The success of immunization with irradiated sporozoites is unparalleled among the current
vaccination approaches against malaria, but its mechanistic underpinnings have yet to be …

Parasitized red blood cells (RBCs) from children suffering from severe malaria often adhere
to complement receptor 1 (CR1) on uninfected RBCs to form clumps of cells known as “…

The diversity of circulating human B cells is unknown. We use single-cell RNA sequencing (RNA-seq)
to examine the diversity of both antigen-specific and total B cells in healthy …

Liver-resident CD8 + T cells are highly motile cells that patrol the vasculature and provide
protection against liver pathogens. A key question is: How can these liver CD8 + T cells be …

Experimental visceral leishmaniasis (VL) represents an exquisite model to study CD8 + T
cell responses in a context of chronic inflammation and antigen persistence, since it is …

Cerebral malaria (CM) is a major complication of Plasmodium falciparum infection in
children. The pathogenesis of CM involves vascular inflammation, immune stimulation, and …