User profiles for I. M. Flyamer
 | Ilya FlyamerFriedrich Miescher Institute for Biomedical Research Verified email at fmi.ch Cited by 2377 |
Single-nucleus Hi-C reveals unique chromatin reorganization at oocyte-to-zygote transition
Chromatin is reprogrammed after fertilization to produce a totipotent zygote with the potential
to generate a new organism 1 . The maternal genome inherited from the oocyte and the …
to generate a new organism 1 . The maternal genome inherited from the oocyte and the …
Active chromatin and transcription play a key role in chromosome partitioning into topologically associating domains
…, EE Khrameeva, AA Gavrilov, IM Flyamer… - Genome …, 2016 - genome.cshlp.org
Recent advances enabled by the Hi-C technique have unraveled many principles of chromosomal
folding that were subsequently linked to disease and gene regulation. In particular, Hi-…
folding that were subsequently linked to disease and gene regulation. In particular, Hi-…
A mechanism of cohesin‐dependent loop extrusion organizes zygotic genome architecture
Fertilization triggers assembly of higher‐order chromatin structure from a condensed
maternal and a naïve paternal genome to generate a totipotent embryo. Chromatin loops and …
maternal and a naïve paternal genome to generate a totipotent embryo. Chromatin loops and …
Cohesin is required for long-range enhancer action at the Shh locus
L Kane, I Williamson, IM Flyamer, Y Kumar… - Nature structural & …, 2022 - nature.com
The regulatory landscapes of developmental genes in mammals can be complex, with
enhancers spread over many hundreds of kilobases. It has been suggested that three-…
enhancers spread over many hundreds of kilobases. It has been suggested that three-…
Developmentally regulated Shh expression is robust to TAD perturbations
…, L Kane, PS Devenney, IM Flyamer… - …, 2019 - journals.biologists.com
Topologically associating domains (TADs) have been proposed to both guide and constrain
enhancer activity. Shh is located within a TAD known to contain all its enhancers. To …
enhancer activity. Shh is located within a TAD known to contain all its enhancers. To …
[HTML][HTML] MCM complexes are barriers that restrict cohesin-mediated loop extrusion
Eukaryotic genomes are compacted into loops and topologically associating domains (TADs)
1 , 2 – 3 , which contribute to transcription, recombination and genomic stability 4 , 5 . …
1 , 2 – 3 , which contribute to transcription, recombination and genomic stability 4 , 5 . …
A central role for canonical PRC1 in shaping the 3D nuclear landscape
S Boyle, IM Flyamer, I Williamson… - Genes & …, 2020 - genesdev.cshlp.org
Polycomb group (PcG) proteins silence gene expression by chemically and physically
modifying chromatin. A subset of PcG target loci are compacted and cluster in the nucleus; a …
modifying chromatin. A subset of PcG target loci are compacted and cluster in the nucleus; a …
[HTML][HTML] Nuclear lamina integrity is required for proper spatial organization of chromatin in Drosophila
…, VV Nenasheva, AA Ilyin, IM Flyamer… - Nature …, 2019 - nature.com
How the nuclear lamina (NL) impacts on global chromatin architecture is poorly understood.
Here, we show that NL disruption in Drosophila S2 cells leads to chromatin compaction and …
Here, we show that NL disruption in Drosophila S2 cells leads to chromatin compaction and …
Coolpup.py: versatile pile-up analysis of Hi-C data
… Ilya M Flyamer , Ilya M Flyamer … Approaches to analyse strength of loops, TADs and genome
compartmentalization from such data genome wide have been developed (Flyamer et al., …
compartmentalization from such data genome wide have been developed (Flyamer et al., …
[PDF][PDF] DNA methylation directs polycomb-dependent 3D genome re-organization in naive pluripotency
The DNA hypomethylation that occurs when embryonic stem cells (ESCs) are directed to the
ground state of naive pluripotency by culturing in two small molecule inhibitors (2i) results in …
ground state of naive pluripotency by culturing in two small molecule inhibitors (2i) results in …