Disease modeling and target identification are the most crucial initial steps in drug discovery,
and influence the probability of success at every step of drug development. Traditional …

While many efforts have been made to pave the way toward human space colonization, little
consideration has been given to the methods of protecting spacefarers against harsh …

A majority of cancers fail to respond to immunotherapy with antibodies targeting immune
checkpoints, such as cytotoxic T-lymphocyte antigen-4 (CTLA-4) or programmed death-1 (PD-1)…

The application of artificial intelligence (AI) has been considered a revolutionary change in
drug discovery and development. In 2020, the AlphaFold computer program predicted protein …

… Ozerov Ivan V. Ozerov 1 Evgeny Putin, Evgeny Putin 1,3 Ekaterina Skibina Ekaterina
Skibina 1 Franco Cortese Franco Cortese 4 Alex Zhavoronkov,, Alex Zhavoronkov 1,4,5 …

… out a phase 0 single-micro-dose study in healthy participants (ACTRN12621001541897)
to evaluate INS018_055 pharmacokinetics (PK), in which we observed that an intravenous …

Signalling pathway activation analysis is a powerful approach for extracting biologically relevant
features from large-scale transcriptomic and proteomic data. However, modern pathway-…

Aging biology is a promising and burgeoning research area that can yield dual-purpose
pathways and protein targets that may impact multiple diseases, while retarding or possibly …

Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease with ill-defined
pathogenesis, calling for urgent developments of new therapeutic regimens. Herein, we …

Aging is a complex and multifactorial process that increases the risk of various age-related
diseases and there are many aging clocks that can accurately predict chronological age, …