SM comprises a heterogeneous group of disorders, characterized by an abnormal accumulation
of clonal MCs in 1 or more tissues, frequently involving the skin and BM. Despite the fact …

Improvements in genomic and molecular methods are expanding the range of potential
applications for circulating tumour DNA (ctDNA), both in a research setting and as a 'liquid biopsy…

Recently, there has been an increasing interest in the development and characterization of
patient-derived tumor xenograft (PDX) models for cancer research. PDX models mostly retain …

The goals of this study were to evaluate the efficacy of benznidazole (Bz) treatment in
decreasing of the parasitic load during the acute phase of experimental Chagas disease and to …

All cancers are caused by somatic mutations; however, understanding of the biological
processes generating these mutations is limited. The catalogue of somatic mutations from a …

Since its initial release in 2000, the human reference genome has covered only the
euchromatic fraction of the genome, leaving important heterochromatic regions unfinished. …

Background The management of metastatic breast cancer requires monitoring of the tumor
burden to determine the response to treatment, and improved biomarkers are needed. …

CpG island hypermethylation and global genomic hypomethylation are common epigenetic
features of cancer cells. Less attention has been focused on histone modifications in cancer …

Primary triple-negative breast cancers (TNBCs), a tumour type defined by lack of oestrogen
receptor, progesterone receptor and ERBB2 gene amplification, represent approximately 16…

We analysed whole-genome sequences of 560 breast cancers to advance understanding of
the driver mutations conferring clonal advantage and the mutational processes generating …